卡托普利治疗老年高血压伴轻度肾损害的疗效及对肾功能转归的影响

目的探讨卡托普利治疗老年高血压伴轻度肾损害的疗效及对肾功能转归的影响。方法将该院2011~2014年收治的150例老年高血压伴轻度肾损害患者随机分为观察组(n=79)与对照组(n=71),对照组给予非洛地平联合厄贝沙坦治疗,观察组给予卡托普利联合厄贝沙坦治疗,观察两组治疗前后血压水平、肾内血流动力学、临床疗效及肾功能指标。结果两组治疗后收缩压(SBP)、舒张压(DBP)及搏动指数(PI)低于治疗前(P0.05)。观察组治疗后SBP、DBP、肾动脉阻力指数(RI)及PI低于对照组,差异有统计学意义(P0.05)。观察组临床总有效率为96.2%(76/79),对照组临床总有效率为84.5%(60/71),两组差异有统计学意义(P0.05)。治疗后,观察组血清肌酐(Cr)、尿素氮(BUN)及尿酸(UA)水平与对照组比较差异无统计学意义(P0.05);而观察组血清胱抑素-C(Cys-C)、尿微量清蛋白(mALB)和β_2-微球蛋白(β_2-MG)水平则低于对照组,两组差异有统计学意义(P0.05)。结论卡托普利联合厄贝沙坦能有效控制患者血压水平,减小高血压导致的肾功能损害。

Efficacy of captopril in treating elderly hypertension complicating mild renal damage and its impact on renal function outcome

Objective To explore the clinical efficacy of captopril in the treatment of elderly hypertension com‐plicating mild renal damage and its impact on the renal function outcome .Methods A total of 150 cases of elderly hy‐pertension complicating mild renal damage in our hospital during 2011-2014 were randomly divided into the observa‐tion group(n=79) and the control group(n=71) .The control group was treated with felodipine combined with irbe‐sartan ,while the observation group was treated with captopril combined with irbesartan .The blood pressure ,intra‐renal hemodynamics ,clinical efficacy and renal function indicators were observed in the two groups .Results After treatment ,SBP ,DBP and PI in the two groups were significantly lower than before treatment(P<0 .05) .SBP ,DBP , RI and PI in the observation group were lower than those in the control group (P<0 .05) .The total clinical effective rate of the observation group was 96 .2% (76/79) and which of the control group was 84 .5% (60/71) ,and the differ‐ence had statistical significance (P<0 .05) .The level of serum Cr ,BUN and UA after treatment had no statistically significant difference between the observation group and the control group (P> 0 .05) ,however ,the observation group were significantly lower than the control group in the levels of serum Cys‐C ,urinary mALb and β2‐MG ,the differences were statistically significant(P<0 .05) .Conclusion Captopril combined with irbesartan could effectively control the level of blood pressure and reduces the hypertension induced renal damage .