血小板参数在3种疾病诊断中的临床价值

目的探讨血小板参数在肝硬化、脑梗死、尿毒症3种疾病中的变化情况。方法对238例不同疾病患者进行血小板计数(PLT)、平均血小板体积(MPV)、血小板压积(PCT)、血小板分布宽度(PDW)4项参数测定,并与96例健康对照组比较。结果肝硬化组PLT、PCT明显低于健康对照组(P0.01),MPV、PDW高于健康对照组(P0.05)。肝硬化出血组PLT、MPV、PCT低于无出血组(P0.05),PDW无明显变化。脑梗死组PLT低于健康对照组,而MPV高于健康对照组,差异均有统计学意义(P0.05),PCT、PDW无明显变化。脑梗死组治疗后MPV比治疗前降低(P0.05)。尿毒症组PLT低于健康对照组(P0.05),PDW、MPV高于健康对照组(P0.05),PCT变化不明显。结论血小板参数的联合监测对3种疾病的诊断、治疗、预后观察有重要临床价值。

Clinical value of platelet parameters in diagnosis of 3 kinds of diseases

Objective To investigate the changes of platelet parameters in liver cirrhosis ,cerebral infarction and uremia .Methods Platelet count (PLT) ,mean platelet volume (MPV) ,plateletcrit (PCT) and platelet distribu‐tion width (PDW) were measured in 238 patients with different diseases and and the detection results were compared with those detected in 96 normal controls .Results PCT and PLT in the liver cirrhosis group were significantly lower than those in the healthy controls (P< 0 .01) ,while MPV and PDW were higher than those in the control group (P<0 .05) .PLT ,PCT and MPV in the liver cirrhosis bleeding group were lower than those in the non‐bleeding group (P<0 .05) ,while no significant change was found and PDW ;PLT in the cerebral infarction group was signifi‐cantly lower than that in the healthy control group ,the difference was statistically significant (P<0 .05) ,while MPV was significantly higher than that in the control group with statistical difference(P<0 .05) .No significant changes in PDW and PCT were found .MPV after treatment in the cerebral infarction group was decreased compared with before treatment (P<0 .05) .PLT in the uremic group was lower than that in the healthy control group (P<0 .05) ,while MPV and PLT were significantly higher than those in the healthy control group (P<0 .05) ,no significant change was found in PCT .Conclusion The combined detection of platelet parameters has an important clinical value in the diagnosis ,treatment and prognosis of liver cirrhosis cerebral infarction and uremia .