慢性肾脏病3~5期患者骨代谢相关指标分析

目的探讨慢性肾脏病(CKD)3~5期患者血清骨代谢相关指标水平的变化情况,为继发性骨代谢疾病的早期诊断与预防提供依据。方法回顾性分析本院收治的确诊为CKD 3~5期的261例患者血清中甲状旁腺激素(iPTH)、钙(Ca)、磷(P)、骨钙素(BGP)、降钙素(CT)、骨特异性碱性磷酸酶(OST)、25-羟基维生素D[25(OH)D]等指标水平的变化,并与反映肾脏功能的血清尿素(Urea)、尿酸(UA)、血肌酐(SCr)等指标进行相关性分析。结果在CKD 3~5期,血清iPTH和P水平进行性升高,差异有统计学意义(P0.05);BGP和CT在CKD5期明显升高,差异有统计学意义(P0.01)。Spearman相关分析显示,iPTH、P与Urea、UA、SCr均呈正相关(P0.05)。结论 CKD 3~5期iPTH、P、BGP等指标有差异,并与Urea、UA和SCr等指标呈正相关,可辅助诊断骨代谢疾病。

Analysis of serum bone metabolism related indexes in patients with stages 3-5 chronic kidney disease

Objective To investigate the changes of the serum bone metabolism indexes levels in the patients with stages 3 - 5 chronic kidney disease(CKD) to provide the evidence for the diagnosis and prevention of secondary bone metabolic diseases .Methods Totally 261 patients with stages 3 - 5 CKD in our hospital were performed the retrospective analysis on the levels of serum iPT H ,Ca ,P ,BGP ,CT ,OST and 25(OH)D and the correlation analysis with the indexes of Urea ,UA and SCr .Results The levels of iPT H and P were increased continuously in the stages 3 - 5 CKD ,the differences were statistically significant (P< 0 .05) .The serum BGP and CT were significantly higher in the patients with stage 5 CKD with statistical difference (P< 0 .01) .The Spearman′s correlation analysis showed that iPT H and P were positively correlated with Urea ,UA and SCr (P < 0 .05) .Conclusion The levels of iPT H ,P and BGP in the patients with stages 3 - 5 CKD are significantly different ,and show the positive correlation with Urea ,UA and SCr ,which is helpful for diagnosing bone metabolic diseases .