右美托咪定联合舒芬太尼应用于结肠癌术后的镇痛效果

目的探讨结肠癌手术后应用右美托咪定联合舒芬太尼的镇痛效果。方法将118例全身麻醉行结肠癌根治术的患者随机分为对照组(舒芬太尼+高乌甲素+雷莫司琼进行静脉自控镇痛)与观察组(右美托咪定+舒芬太尼+高乌甲素+雷莫司琼进行静脉自控镇痛),每组各59例。采用疼痛视觉模拟评分法(VAS)分别评价两组患者术后1、3、6、12、24、48h疼痛情况,统计两组患者切口刺激疼痛敏感面积及不良反应情况。结果观察组术后24h内各时间点VAS评分均明显低于对照组,差异均有统计学意义(P0.05);观察组术后24、48、72h切口机械性刺激疼痛敏感面积分别为(12.8±2.4)、(24.7±2.9)、(23.9±3.2)cm2明显少于对照组的(32.9±3.6)、(56.8±4.1)、(53.6±3.6)cm~2,差异均有统计学意义(P0.05)。两组治疗期间均无明显不良反应。结论于全身麻醉行结肠癌根治术期间应用右美托咪定联合舒芬太尼具有较好镇痛效果。

Analgesic effect of dexmedetomidine combined with sufentanil applied after colon cancer operation

Objective To investigate the analgesic effect of dexmedetomidine combined with sufentanil after colon cancer operation .Methods Totally 118 cases of colon cancer radical operation under general anesthesia were randomly divided into the control group (sufentanil + lappaconitine + ramosetron by intravenous self control anal‐gesia) and the observation group (dexmedetomidine + sufentanil + lappaconitine + ramosetron by intravenous self control analgesia) ,59 cases in each group;the pain visual analogue scale (VAS) was adopted to evaluate the pain sit‐uation in the two groups at postoperative 1 ,3 ,6 ,12 ,24 ,48 h ,and the incision stimulating pain sensitive area and ad‐verse reactions were performed the statistics in the two groups .Results The VAS scores at various time pointsin the observation group were significantly lower than those in the control group ,the difference was statistically signifi‐cant(P<0 .05);the incision mechanical stimulating pain sensitive area at postoperative 24 ,48 ,72 h in the observation group were (12 .8 ± 2 .4) ,(24 .7 ± 2 .9) ,(23 .9 ± 3 .2)cm2 respectively ,which were significantly less than in (32 .9 ± 3 .6) ,(56 .8 ± 4 .1) ,(53 .6 ± 3 .6)cm2 in the control group ,the differences were statistically significant(P<0 .05) .No obvious adverse reactions occurred during the treatment period .Conclusion Using dexmedetomidine combined with sufentanil has better analgesic effect in colon cancer radical operation under general anesthesia .