| 挥发性有机物对小鼠脑组织形态学和氨基酸类递质的影响 |
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| 引用本文： | 张焕珠,宋伟民. 挥发性有机物对小鼠脑组织形态学和氨基酸类递质的影响[J]. 卫生研究, 2007, 36(3): 269-272 |
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| 作者姓名： | 张焕珠 宋伟民 |
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| 作者单位： | 1. 上海市黄浦区疾病预防控制中心
2. 复旦大学公共卫生学院劳动卫生与环境卫生学教研室,上海,230032 |
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| 摘 要： | 目的通过挥发性有机物(VOCs)对小鼠脑组织中递质类氨基酸含量的影响,探讨VOCs对小鼠神经系统的毒性。方法采用静式吸入染毒,小鼠亚急性暴露于挥发性有机物,设置对照、低(甲醛1.5mg/m3;VOCs20mg/m3)、中(甲醛4.5mg/m3;VOCs60mg/m3)、高浓度暴露组(甲醛13.5mg/m3;VOCs180mg/m3),染毒结束后,做脑组织常规病理,采用高效液相色谱法测定小鼠脑组织(皮质和海马)氨基酸类递质[包括兴奋性氨基酸类递质谷氨酸(Glu)、门冬氨酸(ASP);抑制性氨基酸类递质氨基丁酸(GABA)、甘氨酸(Gly)]含量。结果暴露组小鼠脑组织皮质和海马兴奋性氨基酸类递质含量随染毒浓度增加而降低,而抑制性氨基酸类递质含量随染毒浓度增加而增加。脑组织病理表现为VOCs暴露组神经元变性坏死。结论挥发性有机物引起小鼠学习记忆能力下降和麻醉作用。
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| 关 键 词： | 挥发性有机物 抑制性氨基酸类递质 兴奋性氨基酸类递质 学习记忆 氨基酸 |
| 文章编号： | 1000-8020（2007）03-0269-04 |
| 修稿时间： | 2006-06-30 |
Effects of volatile organic compounds on brain amino acid neurotransmitter in mice |
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| ZHANG Huanzhu,SONG Weimin. Effects of volatile organic compounds on brain amino acid neurotransmitter in mice[J]. Journal of hygiene research, 2007, 36(3): 269-272 |
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| Authors: | ZHANG Huanzhu SONG Weimin |
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| Affiliation: | School of Public Health, Fudan University, Shanghai 200032, China |
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| Abstract: | Objective Study adverse effects of volatile organic compounds volatile organic compounds(VOCs) on brain amino acid neurotransmitter in mice. Methods Four groups of mouse were respectively exposed to 0,low, middle and high concentration of VOCs for two hours every day for 30 days. The content of brain amino acid neurotransmitter was determined. Results The result showed that the content of Glu and ASP in brain of VOCs-exposed mouse decreased and GABA and Gly increased compared with that of control. Conclusion The memory impair in mice induced by exposing VOCs may relate to the chang of content of amino acid neurotransmitter. |
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| Keywords: | volatile organic compounds amino acid neurotransmitter memory |
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