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Central nervous system lupus: Concomitant occurrence of myelopathy and cognitive dysfunction |
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| Authors: | Dr. H. D. Stahl Md Ph.D. F.R.A.C.P. T. H. Ettlin A. Plohmann E. W. Radü J. Müller-Brand U. Steiger A. Tyndall |
| Affiliation: | (1) University Department of Neurology, Kantonsspital Basel, Switzerland;(2) University Department of Nuclear Medicine, Kantonsspital Basel, Switzerland;(3) University Department of Neuroradiology, Kantonsspital Basel, Switzerland;(4) Department of Rheumatology, Felix Platter Spital, Burgfelderstr. 101, 4012 Basel, Switzerland |
| Abstract: | Summary Reported are two cases of patients with central nervous system systemic lupus erythematosus (SLE) with clinical features of a myelopathy confirmed by magnetic resonance imaging (MRI). In one case, further evaluation including Single Photon Emission Computerized Tomography (SPECT) and neuropsychological testing, indicated higher cortical deficits which improved after treatment with monthly pulse intravenous cyclophosphamide. Subsequent cessation of cyclophosphamide was associated with further progression of the neurological disease in this patient. |
| Keywords: | Systemic Lupus Erythematosus Myelopathy Cognitive Dysfunction Magnetic Resonance Imaging Single Photon Emission Computerized Tomography Immunosuppression |
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