米非司酮联合左炔诺孕丙酮宫内缓释系统治疗子宫腺肌病导致不孕症疗效观察

目的：观察米非司酮联合左炔诺孕丙酮缓释系统（LNG-IUS）治疗子宫腺肌病导致不孕症的临床疗效。方法将本院2010年5月～2011年8月收治的子宫腺肌病导致的不孕症患者60例，随机分成治疗组和对照组两组。治疗组：予以米非司酮25mg，每日一次口服，连服3个月。并且所有患者均在签署知情同意书后自愿使用左炔孕丙酮宫内缓释系统。经彩超检查后，由专人于月经第3～7天在用药同时放置左炔诺孕丙酮宫内缓释系统。6个月后取出。对照组：单独给予米非司酮25mg，每日一次口服，连服3个月。观察停药后1、3、6、12个月的怀孕成功率。结果随访至12个月时统计，治疗组平均受孕率79%，对照组平均受孕率57%，治疗组总有效率明显高于对照组（P＜0.05）。结论使用米非司酮联合左炔诺孕丙酮宫内缓释系统治疗子宫腺肌病可以明显提高患者的受孕率，对于子宫腺肌病导致的不孕症疗效好于其他方法，而且经济、安全，便于患者接受。

Observation of the curative effect of mifepristone combined with infertility caused left levonorgestrel releasing intrauterine system in acetone in treatment of adenomyosis

Objective To observe the curative effect of mifepristone combined with infertility caused left levonorgestrel releasing intrauterine system in acetone in treatment of adenomyosis. Methods 60 infertility patients in our hospital from 2010 May to 2011 August were adenomyosis in patients, randomly divided into treatment group and control group two groups.Treatment group was given mifepristone 25mg orally, once a day, and even served three months. And all the patients after informed consent voluntary use of levonorgestrel releasing intrauterine system in acetone, by color Doppler ultrasound examination, by hand in 3-7 days in the menstrual medication at the same time, place left levonorgestrel releasing intrauterine system in acetone, removed after 6 months. Control group was given mifepristone 25mg orally, once a day, and even served three months. The pregnancy, 3, 6, 1 and 12 months were observed after stopping drug. Results Statistics were followed for up to 12 months, the average conception rate of treatment group 79%, control group mean pregnancy rate was 57%, total effective rate of the treatment group was significantly higher than the control group（P 〈 0.05）. Conclusion The use of mifepristone combined with left levonorgestrel releasing intrauterine system in acetone treatment of uterine adenomyosis patients can significantly improve the conception rate, the effect of adenomyosis infertility due to better than other methods, but also economic, security, convenient for patients to accept.