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BPH患者中淀粉样变发生情况及临床特征
引用本文:严景民,辛海贝,任力,穆大为,邢继章,刘红明,潘广新,周高标,孙斌,洪泉,郭和清.BPH患者中淀粉样变发生情况及临床特征[J].临床泌尿外科杂志,2014(1):27-30.
作者姓名:严景民  辛海贝  任力  穆大为  邢继章  刘红明  潘广新  周高标  孙斌  洪泉  郭和清
作者单位:解放军空军总医院泌尿外科;解放军空军总医院病理科;
基金项目:空军总医院科研计划课题项目(编号kz2012021)
摘    要:目的:探讨BPH患者中淀粉样变的发生情况及临床特征,揭示淀粉样变在BPH发生、发展过程中所起的可能作用。方法:采用刚果红染色方法,检测2009~2011年136例在我院行TURP切除标本中淀粉样变的发生情况,分析其与年龄、前列腺体积及其他前列腺疾病的相关性。结果:BPH患者中淀粉样变总阳性表达率为58.8%(80/136)。随着年龄增长,前列腺淀粉样变阳性率显著增加(P0.05),前列腺淀粉样变阳性率与前列腺体积无相关性(P0.05);淀粉样变阳性患者中无伴发前列腺癌(PCa)者,而淀粉样变阴性患者中8.9%(5/56)伴发PCa,二者之间差异有统计学意义(P0.05)。淀粉样变阳性患者中5.0%(4/80)伴发组织学前列腺炎,阴性患者中5.4%(3/56)伴发组织学前列腺炎,二者之间无统计学意义(P0.05)。结论:BPH中淀粉样变发生率随着年龄的增长而增加,但与前列腺体积无关,伴有淀粉样变的BPH中未发现恶性肿瘤,BPH中淀粉样变的发生与是否伴发前列腺炎无相关性。

关 键 词:前列腺增生  淀粉样变  淀粉样小体  前列腺癌  刚果红染色

Incidence and clinical characteristics of amyloidosis of prostates in BPH patients
YAN Jingmin,XIN Haibei,REN Li,MU Dawei,XING Jizhang,LIU Hongming,PAN Guangxin,ZHOUGaobiao,SUN Bin,HONG Quan,GUO Heqing.Incidence and clinical characteristics of amyloidosis of prostates in BPH patients[J].Journal of Clinical Urology,2014(1):27-30.
Authors:YAN Jingmin  XIN Haibei  REN Li  MU Dawei  XING Jizhang  LIU Hongming  PAN Guangxin  ZHOUGaobiao  SUN Bin  HONG Quan  GUO Heqing
Institution:1Department of Urology, General Hospital of AirForce, PLA, Beijing, 100142, China; 2Department of Pathology, General Hospital of AirForce)
Abstract:Objective: To investigate the incidence and clinical characteristics of prostatic amyloidosis in BPH patients so as to reveal the possible role of amyloidosis in the process of prostatic pathogenesis. Method: We retro- spectively evaluated the incidence of prostatic amyloidosis of 136 specimens obtained by transurethral resection of prostate after Congo red staining from 2009 to 2011, and analyzed the correlation between BPH and patients age, prostate volume, other prostatic diseases respectively. Result: The incidence of prostatic amyloidosis in BPH pa- tients was 58.8 % (80/136). The incidence of prostatic amyloidosis increased significantly along with the increase of the age (P〈0.05). The incidence of prostatic amyloidosis was not correlated with prostate volume (P〉0.05). There was no prostate cancer cases in the patients with prostatic amyloidosis. However, there were five prostate cancer cases in 56 patients without prostatic amyloidosis (8.9%). There was a significant difference between the two groups (P〈0.05). There were four histological prostatitis cases in 80 patients with prostatic amyloidosis (5.0%), and there were three histological prostatitis cases in 56 patients without prostatic amyloidosis (5.4%). No significant difference between the two groups appeared (P〉0.05). Conclusion: There is a positive correlation between patients" age and the incidence of prostatic arnyloidosis. However, no correlation is found between pros- tate vlolume and the incidence of prostatic amyloidosis. Prostate cancer is not found in BPH patients combined with prostatic amyloidosis. There is no correlation between prostatitis and prostatic amyloidosis in BPH patients.
Keywords:benign prostatic hyperplasia  amyloidosis  corpora amylacea  prostate cancer  Congo red staining
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