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| 风湿性心脏病患者心肌肌球蛋白轻链的变化 | |
| 引用本文： | 史沁卫,朱泉芳,吴弘,郝家骅,张宝仁,朱家麟,郎希龙. 风湿性心脏病患者心肌肌球蛋白轻链的变化[J]. 第二军医大学学报, 1999, 20(5): 325-326 |
| 作者姓名： | 史沁卫 朱泉芳 吴弘 郝家骅 张宝仁 朱家麟 郎希龙 |
| 作者单位： | 1. 第二军医大学长海医院胸心外科,上海,200433 2. 第二军医大学,长海医院心血管内科 3. 加拿大多伦多大学临床生化研究室 |
| 摘 要： | 目的:研究风湿性心脏病(RHD)心衰时心室肌中肌球蛋白轻链(VMLC)的变化与心脏重塑的关系。方法:采用Western blotting技术对13例RHD心衰患者及7例意外死亡者VMLC-1,VMLC-2含量进行定量分析。结果:RHD组VMLC-1,VMLC-2含量均显著低于正常对照组,以VMLC-2含量下降最明显,VMLC-1/VMLC-2比值在1∶0.95-1∶0.61。结论:RHD心衰发展过程中涉及了VMLC-1,VMLC-2蛋白水平的改变,这种改变可能对心功能的进行性恶化有直接影响。 |
| 关 键 词： | 风湿性心脏病 心脏重塑 肌球蛋白轻链,心室型 |
Alterations of myosin light chains in ventricular myocardium in patients with rheumatic heart disease |
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| Lang Xilong,Zhu Jialin,Zhang Baoren,Hao Jiahua,Wu Hong,Zhu Quanfang,Shi Qinwei. Alterations of myosin light chains in ventricular myocardium in patients with rheumatic heart disease[J]. Former Academic Journal of Second Military Medical University, 1999, 20(5): 325-326 | |
| Authors: | Lang Xilong Zhu Jialin Zhang Baoren Hao Jiahua Wu Hong Zhu Quanfang Shi Qinwei |
| Abstract: | Objective: To study the changes of ventricular myosin light chain (VMLC) and its relation with heart remodeling in rheumatic heart disease (RHD). Methods: Using Western blotting hybridization assay, we detected VMLC1, VMLC2 in 13 patients with RHD and 7 cases of accidental deathes. Results: As compared with the normal group, the contents of VMLC1 , VMLC2 were all decreased significantly in RHD patients, especially the VMLC2. The ratio of VMLC1/VMLC2 in RHD patients varied from 10.95 to 10.61. Conclusion: The values of VMLC1, VMLC2 and the ratio of VMLC1/VMLC2 are all changed during the development of heart remodeling in RHD patients, suggesting that these changes may exert a direct effect on the progressive deterioration of heart function. |
| Keywords: | rheumatic heart disease heart remodeling myosin light chain, ventricle |
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