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Nonalcoholic fatty liver disease and HFE gene mutations: A Polish study |
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| Authors: | Joanna Raszeja-Wyszomirska Grzegorz Kurzawski Malgorzata Lawniczak Joanna Miezynska-Kurtycz Jan Lubinski |
| Affiliation: | Joanna Raszeja-Wyszomirska, Joanna Miezynska-Kurtycz, Liver Unit, Pomeranian Medical University, 70-111 Szczecin, PolandGrzegorz Kurzawski, Jan Lubinski, Department of Genetics and Pathology, International Hereditary Cancer Centre, Pomeranian Medical University, 70-111 Szczecin, PolandMalgorzata Lawniczak, Department of Gastroenterology, Pomeranian Medical University, 71-252 Szczecin, Poland |
| Abstract: | AIM:To describe a Polish population with nonalcoholic fatty liver disease(NAFLD)with regard to HFE gene mutations,as well as analyzing demographic and clinical data.METHODS:Sixty-two consecutive patients with biopsy-proven NAFLD were included in the study.Demographic,clinical,and laboratory data were summarized in a database.C282Y and H63D mutations of the HFE gene were analyzed using polymerase chain reactionrestriction fragment lenght polymorphism.RESULTS:The analyzed cohort consisted of 62 homo-geneic Ca... |
| Keywords: | Nonalcoholic fatty liver disease HFE gene mutations Liver fibrosis |
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| 点击此处可从《World journal of gastroenterology : WJG》浏览原始摘要信息 | |