Maternal hyperglycemia and adverse pregnancy outcomes in Dar es Salaam,Tanzania |
| |
Authors: | Anne Marie Darling Enju Liu Said Aboud Willy Urassa Donna Spiegelman Wafaie Fawzi |
| |
Affiliation: | 1. Department of Global Health and Population, Harvard School of Public Health, Boston, USA;2. Department of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania;3. Department of Epidemiology, Harvard School of Public Health, Boston, USA;4. Department of Biostatistics, Harvard School of Public Health, Boston, USA;5. Department of Nutrition, Harvard School of Public Health, Boston, USA |
| |
Abstract: | ObjectiveTo evaluate maternal glucose levels during pregnancy as a predictor of adverse perinatal outcomes in Dar es Salaam, Tanzania.MethodsRandom blood glucose measurements were analyzed from 3383 pregnant women enrolled in a randomized trial to assess the impact of multivitamins on pregnancy outcomes in Dar es Salaam between August 2001 and July 2004. Information on maternal and neonatal morbidity was recorded at monthly study visits, delivery, and 6 weeks postpartum. Binomial regression and generalized estimating equations were used to determine the relationship between elevated glucose (> 7.8 mmol/L) and pregnancy outcomes.ResultsIn total, 25 women had elevated glucose (0.7%). Hyperglycemia was associated with an increased risk of delivery before 37 weeks [relative risk (RR), 2.11; 95% confidence interval [CI], 1.07–4.13; P = 0.03), delivery before 34 weeks (RR, 4.15; 95% CI, 1.43–12.03, P = 0.009), incident gestational hypertension (RR, 2.90; 95% CI, 1.24–6.76; P = 0.01), low birth weight (RR, 2.87; 95% CI, 1.18–6.99; P = 0.02), reduced newborn head circumference (mean difference, –1.57; 95% CI, –2.51 to − 0.62; P = 0.001), and fetal loss (RR, 3.38; 95% CI, 1.13–10.08; P = 0.03).ConclusionMaternal hyperglycemia is uncommon among pregnant Tanzanian women, but nonetheless seems to increase the risk of several adverse perinatal outcomes. |
| |
Keywords: | Africa Gestational hyperglycemia Gestational hypertension Low birth weight Preterm birth Stillbirth |
本文献已被 ScienceDirect 等数据库收录! |
|