IgA肾病50例临床病理分析

目的：探讨IgA肾病（IgAN）患者临床与病理类型间的关系，为临床治疗及判断预后提供依据。方法：本文收集经肾活检诊断为原发性IgA肾病的患者资料50例进行临床特点、病理及免疫病理等资料回顾性分析。结果：IgA肾病以血尿并发蛋白尿最多见，占90％，伴发高血压占46％，伴发急性肾功能不全及慢性肾功能不全各占30％，病理分级与临床类型未发现有相关性，与免疫病理类型无密切关系．但病理分级高，提示肾损害严重，预后不良。重度蛋白尿组的血肌酐显著高于轻、中度蛋白尿组。高血压是预后不良因素。结论：大量蛋白尿和高血压可能促进IgA肾病的肾功能损害进展。

Clinical Pathology of IgA Nephropathy CReport of 50 Cases

Objective:To discuss the relationship between clinical manifestation and pathology in IgA nephropathoy,for providing evidence for Clinical treatment and prognosis.Methods: Clinical data of 50 patients with primary IgA nephropa thy diagnosed by biopsy were collected.Their clinical features,pathology and immuno-pathology were retrospectively analyzed.Results: Hematuria and proteinuria were commonest manifes-tations in IgA nephropa thy(90%).46% of patients Oomplicated with hypertension,30% with acute renal failure and 30% with chronic renal failure Through pathologic grade was no correlated with clinical type or immuno pathology,but severe pathologic lesions predict poor prognosis.The level of serum creatinine in group with severe proteinuria was higher than that in group with mild or moderate proteinuria.Hypertension was factors of poor prognosis.Conclusion: Severe proteinuria and hypertension may aggravate the damage in renal function in IgA nephropathy.