Effect of buspiron on formation of acquired helplessness

By decreasing anxiety and emotional stress, buspiron in doses of 1 and 5 mg/kg decelerates the formation of instrumental defense reflex and increases the incidence of acquired helplessness in rats trained under conditions of highly indefinite environment. Buspiron in a dose of 0.5 mg/kg apparently does not affect the optimal emotional background, thus promoting attaining the goal of conditioned reflex activity and not leading to an increase in the incidence of acquired helplessness. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 9, pp. 286–288, September, 1998