| 柴胡剂对单克隆抗体5—1—6引起蛋白尿的实验研究 |
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| 引用本文： | 李平. 柴胡剂对单克隆抗体5—1—6引起蛋白尿的实验研究[J]. 中医杂志, 1995, 36(7): 424-425 |
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| 作者姓名： | 李平 |
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| 作者单位： | 中国中医研究院研究生部，日本新泻大学医学部附属肾病研究所 北京海淀区西苑医院内 100091 |
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| 摘 要： | 静脉一次性注射单克隆抗体5-1-6可引起实验大鼠大量的、一过性的蛋白尿。抗体注射后第1、3、5、8天,柴胡剂治疗组与PBS对照组比较有显著性差异。免疫荧光所见,柴胡剂治疗组中沿肾小球毛细血管壁颗粒样沉积明显减少。口腔灌药柴苓汤对蛋白尿的作用未能得到证实。此实验提示柴胡剂可能通过某种途径改变了大鼠肾小球毛细血管壁的通透性。
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| 关 键 词： | 蛋白尿/中医药疗法 抗体 单克隆 柴胡剂 |
Experimental Study on Effect of Radix Bupleuri Preparations on Proteinuria Induced by 5-1-6 Monoclonal Antibody |
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| Li Ping,Shimizu Fujio. Experimental Study on Effect of Radix Bupleuri Preparations on Proteinuria Induced by 5-1-6 Monoclonal Antibody[J]. Journal of Traditional Chinese Medicine, 1995, 36(7): 424-425 |
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| Authors: | Li Ping Shimizu Fujio |
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| Affiliation: | Li Ping,Shimizu FujioDepartment of Graduate Students,China Academy of TCM,Beijing,100091 |
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| Abstract: | A one - dose 5 - 1 - 6 monoclonal antibody injected intravenously can induce atransient massive proteinuria in rat. Comparison between Radix Bupleuritreating group and PBS control group 1, 3, 5, 8 days after injection showed significant difference. Under immuno -flourescence exam, the granular precipitation along the glomerular capillaries in experimental group decreased distinctively, yet the effect of Chailing Decoction on proteinuria can not be proved by oral infusion, suggesting that Radix Bupleuri may change the permeability of glomerular capillary in rat through certain mechanism. |
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| Keywords: | Proteinuria/TCM therapy antibody monoclone @ Injectionof Radix Bupleuri |
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