Deficits in attention performance are associated with insufficiency of slow-wave sleep in insomnia |
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| Institution: | 1. Sleep Medicine Center, Department of Respiratory and Critical Care Medicine, Translational Neuroscience Center, Department of Otolaryngology, West China Hospital, Sichuan University, Chengdu, China;2. Geriatric Department, The First People''s Hospital of Yibin, China;3. Yale University School of Medicine, New Haven, CT, USA;1. École de Psychologie, Université Laval, Québec, QC, Canada;2. Laboratoire de Sommeil et Potentiels Évoqués Cognitifs du Centre de Recherche de l''Institut Universitaire en Santé Mentale de Québec, Québec, QC, Canada;3. School of Psychology, University of Ottawa, Ottawa, ON, Canada;4. Northumbria Centre for Sleep Research, Northumbria University, Newcastle, UK;1. Department of Neurology, Chengdu Second People''s Hospital, Chengdu, Sichuan, 610017, China;2. Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 610072, China;3. Department of Neurology, The Third Affiliated Hospital of Anhui Medical University, Heifei, Anhui, 230061, China |
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| Abstract: | ObjectiveCognitive impairment is associated with insomnia. However, there is a lack of evidence suggesting a link between insomnia and cognitive dysfunction in objective testing. The objectives of our current study were to assess the differences in components of attentional performance between primary insomnia patients and normal-sleeping controls and to examine potential predictors of attention impairment in patients with insomnia.MethodsWe studied 36 patients (age 40.39 ± 12.36 years; 57.1% male) with insomnia and 25 normal-sleeping controls (age 39.88 ± 12.50 years; 52.9% male) who underwent one-night polysomnography followed by Multiple Sleep Latency Test (MSLT) and Attention Network Task (ANT). ANT reflected three attentional networks termed the alerting, orienting, and executive control networks.ResultsAfter controlling for age, gender, body mass index, depression, anxiety, and education levels, patients with insomnia scored higher on the executive control variable of the ANT compared with normal-sleeping controls (96.75 ± 7.60 vs. 57.00 ± 10.49, p = 0.01). This higher score was independently associated with insufficiency of slow-wave sleep during nighttime sleep (β = −0.38, p = 0.04).ConclusionOur findings suggest that insomnia is associated with deficits in executive control of attention and that the underlying mechanism may be insufficiency of slow-wave sleep in chronic insomnia. |
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