Increased frequency and severity of restless legs syndrome in patients with neuromyelitis optica spectrum disorder |
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| Affiliation: | 1. Department of Neurology, Research Institute and Hospital of National Cancer Center, Goyang, Republic of Korea;2. Department of Neurology, Dankook University College of Medicine, Dankook University Hospital, Cheonan, Republic of Korea;1. Hospital Moinhos de Vento (HMV), Porto Alegre, Rio Grande do Sul, Brazil;2. Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Brain Institute (InsCer), Porto Alegre, RS, Brazil;1. Neurology Department, Hospital Universitario Son Espases, Illes Balears, Spain;2. Pneumology Department, Sleep Unit, Hospital Universitario Son Espases, Illes Balears, Spain;3. Instituto de Investigación Hospital Universitario de la Princesa (IISP), Universidad Autónoma de Madrid, Madrid, Spain;1. Neurology Service, Hospital Clínic de Barcelona, IDIBAPS, Barcelona, Spain;2. CIBERNED, Barcelona, Spain;1. Department of Otorhinolaryngology, Faculty of Medicine and Dentistry, Medical University of Warsaw, Warsaw, Poland;2. Department of Otolaryngology–Head Neck Surgery, University of Cincinnati, Cincinnati, Ohio, USA;3. Divisions of Pediatric Otolaryngology & Pulmonary Medicine, Cincinnati Children''s Hospital Medical Center, Cincinnati, Ohio, USA;4. Third Department of Psychiatry and Sleep Disorders Center, Institute of Psychiatry and Neurology, Warsaw, Poland |
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| Abstract: | ObjectivesTo investigate the comorbidity of restless legs syndrome (RLS) and neuromyelitis optica spectrum disorder (NMOSD).MethodsThis study enrolled 159 NMOSD patients and 153 age- and gender-matched healthy controls. All participants completed a questionnaire based on the updated International Restless Legs Syndrome Study Group consensus criteria, the International RLS Severity scale, Epworth Sleepiness Scale, Fatigue Severity Scale, and Pittsburgh Sleep Quality Index, and were subsequently interviewed by a neurologist. The frequency and features of RLS were compared between NMOSD patients and healthy controls. The clinical and radiological characteristics of the NMOSD patients with and without RLS were also compared.ResultsThe frequency and severity of RLS were significantly higher in NMOSD patients than in healthy controls (p = 0.015 for both) and NMOSD patients with RLS had a longer disease duration and more severe disability than those without RLS.ConclusionsThis study indicated importance of considering RLS in NMOSD patients. |
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