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Disappearing colorectal liver metastases: Strategies for the management of patients achieving a radiographic complete response after systemic chemotherapy |
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| Authors: | Raphael L. C. Araujo MD PhD Jean Michel Milani MD Daniela Pezzutti Armentano MD Raphael Brandão Moreira MD Gustavo S. F. Pinto MD Luís Antônio de Castro MD Fabiano R. Lucchesi MD PhD |
| Affiliation: | 1. Department of Digestive Surgery, Escola Paulista de Medicina – UNIFESP, São Paulo, Brazil;2. Department of Oncology, Americas Medical Service/Brazil, United Health Group, São Paulo, Brazil;3. Department of Clinical Oncology, Barretos Cancer Hospital, Barretos, Brazil;4. Department of Radiology, Barretos Cancer Hospital, Barretos, Brazil |
| Abstract: | The mainstays of treatment for colorectal liver metastases (CRLMs) are surgery and chemotherapy. Chemotherapeutic benefits of tumor shrinkage and systemic control of micrometastases are in part counterbalanced by chemotoxicity that can modify the liver parenchyma, jeopardizing the detection of CRLM. This review addresses the clinical decision-making process in the context of radiographic and pathologic responses, the preoperative imaging workup, and the approaches to the liver for CRLM, which disappear after systemic chemotherapy. |
| Keywords: | cancer chemotherapy colorectal liver metastases hepatectomy missing metastases |