IL-1RN gene polymorphisms reduces thyroid cancer risk in Chinese Han population |
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| Authors: | Huajing Li Yue Wu Ruimin Zhao Xin Chen Wanli Ren Honghui Li Peng Han Yuan Shao Jiansheng Wang |
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| Affiliation: | 1. Department of Otolaryngology and Head Neck, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China;2. Department of Operation, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China;3. Department of Otolaryngology and Head Neck, Baoji Central Hospital, Baoji, Shaanxi, China;4. Department of Surgical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China |
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| Abstract: | The purpose of this study was to investigate the effect of IL-1RN polymorphisms on thyroid cancer (TC) risk in Han population. Genotypes of four single nucleotide polymorphisms (SNPs) (rs17042888, rs928940, rs3181052, and rs452204) were analyzed by Agena MassARRAY. Meanwhile, we used the logistic regression to calculate the odds ratios (ORs) and 95% confidence intervals (CIs), and significant differences were evaluated by t test and χ2 test. Findings found that allele “G” of rs452204 and rs3181052 in interleukin-1 receptor antagonist (IL-1RN) reduced the risk of TC. (OR = 0.72, 95% CI = 0.55-0.94, p = .017; OR = 0.73, 95% CI = 0.56-0.94, p = .017, respectively). Hierarchical analysis indicated that three SNPs (rs17042888, rs3181052, and rs452204) significantly reduced the risk of TC among females or individuals older than 48 years (p < .05). Our findings indicate that IL-1RN polymorphisms may contribute to a protective role against TC risk. |
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| Keywords: | genetic polymorphism Han Chinese population IL-1RN thyroid cancer |
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