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Establishment of a hepatocellular carcinoma patient-derived xenograft platform and its application in biomarker identification
Authors:Bo Hu  Hong Li  Wei Guo  Yun-Fan Sun  Xin Zhang  Wei-Guo Tang  Liu-Xiao Yang  Yang Xu  Xiao-Yan Tang  Guo-Hui Ding  Shuang-Jian Qiu  Jian Zhou  Yi-Xue Li  Jia Fan  Xin-Rong Yang
Affiliation:1. Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China

Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, People's Republic of China

Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China;2. Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China

Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, People's Republic of China;3. Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, People's Republic of China;4. Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China

Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, People's Republic of China

Institute of Biomedical Sciences, Fudan University, Shanghai, People's Republic of China;5. Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China

Abstract:
Keywords:hepatocellular carcinoma  patient-derived tumor grafts  sorafenib  drug resistance  MAP3K1
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