Rescue high frequency oscillation in neonates with acute respiratory failure |
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Authors: | Preetham Kumar Poddutoor Dinesh Kumar Chirla Kapil Sachane Farhan A R Shaik Alla Venkatlakshmi |
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Institution: | (1) Department of Medicine, Mount Sinai Hospital and University of Toronto, 600 University Avenue #18-216, Toronto, Ontario, Canada;(2) Interdepartmental Division of Critical Care Medicine, Mount Sinai Hospital and University of Toronto, 600 University Avenue #18-216, Toronto, Ontario, Canada; |
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Abstract: | The aim was to study the efficacy of rescue High Frequency Oscillatory Ventilation (HFOV) in improving the oxygenation and
ventilation in neonates with acute respiratory failure after failing Conventional Mechanical Ventilation (CMV). Primary outcome
was short term oxygenation, lung recruitment, and ventilation and secondary outcome studied was survival. 675 babies were
ventilated and 97 of them received HFOV. HFOV significantly improved oxygenation index, alveolararterial oxygen gradient,
pH, PCO2, PO2 and caused better lung recruitment within 2 hours. Fifty seven babies (58.77%) survived and the mortality was more in <28
weeks, babies with pulmonary hemorrhage, sepsis and CDH. |
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Keywords: | |
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