复合骨水泥椎体间固定的生物力学研究及临床应用

按一定比例将脱钙骨粒(DBP)掺入骨水泥,行成年犬椎体间固定。分别于术后2、4、8、12周时处死。固定段行X线照片、CT扫描及生物力学测试。观察不同时相点的生物力学效应。结果显示:术后2、4周时复合骨水泥的抗压强度低于单纯骨水泥(P〈0.05),8周时两者相近(P〉0.05),12周时高于单纯骨水泥与正常脊柱功能运动单位(FSU)(P〈0.05)。而术后2、4周时,复合骨水泥的抗扭转强度优于单纯骨水泥,2、4、8周时,低于正常FSU,12周时与正常相近。临床应用于胸腰椎骨折侧前方减压后行椎体间固定。术后3个月、6个月CT复查,证明骨已长入骨水泥内。

The Experimental Studies of Biomechanics and Clinical Application in Intervertebra Fixation of Compound Bone Cement

Demineralized bone powder were impregnated into bone cement in regular proportion and were fixed in adult dogs' s intervertebra. Dogs were killed after operation at week 2, 4, 8, 12 for x-ray plaim film. CT image and biomechanical test, so as to observe biomechanical fixative results. The results were: at week 2, 4, The axial compressive load strength of compound bone cement was lower than that of bone cement (P<0. 05). At week 8, the axial compressive load strength of compound bone cement was similar to that of bone cement (P<0. 05). At week 12, the axial comprassive load strength of compound bone cement was higher than that of bone cement and normal spinal functional segment (FSU) (P<0. 05). The torque load strength of compound bone cement was better than that of bone cemtnt and was lower than that of normal FSU at week 12. Intervertebral fixation was applied in 15 casses after anterior decompression of thoracolumbar fractures. The CT images after operation at month 3 month 6 appeared that the bone could grow into compound bone cement.