The possible role of hyperhomocysteinemia on IVF outcome |
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Authors: | Arianna Pacchiarotti Mohamed A. Mohamed Giulietta Micara Antonella Linari Daniela Tranquilli Salomè B. Espinola Cesare Aragona |
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Affiliation: | (1) Obstetric and Gynecology, Policlinico Umberto, La Sapienza University of Rome, Viale Regina Elena, Rome, Italy;(2) Praxi Pro Vita Centro di Fertilità, Via Magnagrecia 117, Rome, Italy |
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Abstract: | Purpose To evaluate the effect of the hyperhomocysteinemia on pregnancy rate, implantation rate and abortion rate after IVF. Method Data from a total of 48 infertile couples with hyperhomocysteinemia were prospectively collected for this study. All patients underwent a standard down regulation protocol for ovarian stimulation. Oocytes recovery was performed at 36 h after hCG administration. Embryo transfer took place at 48 h after insemination. The patients were matched in two groups that received or did not receive therapy (group A and B respectively) to normalize homocysteine plasma level. Results Pregnancy rate, implantation rate and abortion rate varied significantly (p ≤ 0.05) between the two groups. The number and quality of embryos transferred did not differ between the groups. Conclusion The results suggest that hyperhomocysteinemia could affect IVF outcome |
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Keywords: | Hyperhomocysteinemia Implantation rate Pregnancy rate Abortion rate |
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