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| 氯胺酮诱导的大鼠条件性位置偏爱 | |
| 引用本文： | 梅丽娜,王季石,方琴,卢英豪,翟海峰,陆林. 氯胺酮诱导的大鼠条件性位置偏爱[J]. 中国药物依赖性杂志, 2006, 15(4): 277-279 |
| 作者姓名： | 梅丽娜 王季石 方琴 卢英豪 翟海峰 陆林 |
| 作者单位： | 1. 贵阳医学院血液科,贵阳,550004 2. 贵阳医学院药剂科,贵阳,550004 3. 北京大学中国药物依赖研究所,北京,100083 |
| 基金项目： | 国家自然科学基金;贵州省省长基金 |
| 摘 要： | 目的:探讨氯胺酮在大鼠模型上形成条件性位置偏爱(CPP)的特点,分析氯胺酮精神依赖性潜力。方法:(1)60只SD♂大鼠随机分为对照组、氯胺酮及吗啡阳性对照组。(2)氯胺酮组每隔24h腹腔注射氯胺酮10m·lkg-1一次,连续6d,建立大鼠氯胺酮精神依赖性模型,吗啡组给予等剂量的吗啡,对照组则给予等剂量的生理盐水;(3)氯胺酮组及吗啡组于CPP形成后给予生理盐水进行消退实验。结果:(1)氯胺酮组及吗啡组大鼠出现了明显的CPP;(2)与吗啡组相比,氯胺酮组的CPP效应更显著,但消退较快。结论:氯胺酮可诱导大鼠产生CPP,但随着时间的推移CPP消退速度较吗啡快。 |
| 关 键 词： | 氯胺酮 吗啡 条件性位置偏爱 大鼠 |
| 收稿时间： | 2006-01-18 |
| 修稿时间： | 2006-03-21 |
KETAMINE INDUCES RAT CONDITIONED PLACE PREFERECE |
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| MEI Lina,WANG Jishi,FANG Qin,LU Yinghao,ZHAI Haifeng,LU Lin. KETAMINE INDUCES RAT CONDITIONED PLACE PREFERECE[J]. Chinese Journal of Drug Dependence, 2006, 15(4): 277-279 | |
| Authors: | MEI Lina WANG Jishi FANG Qin LU Yinghao ZHAI Haifeng LU Lin |
| Abstract: | Objective:To investingate the potential of differentketamine in the formation ofconditioned place preference(CPP). Methods:(1) 60 Sprague-Dawlay rats were randomly dividedintothree groups for saline control, ketamine and morphine treatment.(2) Ketamine and morphine were administrated at 10 ml[DK]·[DK]kg~ -1 by intraperitoneal injection once a day for 6 days for induction of CPP in the three-chamber apparatus. (3) The formation and extinction of CPP were determined on d1 and d10 after drug conditioning. Results: Ketamine induced a significant rat CPP. Ketamine -induced CPP was extinct more rapidly than that of morphine. Conclusion: Ketamine can induce rat conditioned place preference implying aphysiological dependence potential. |
| Keywords: | ketamine morphine conditioned place preference rat |
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