| 应用SOD后实验性骨痂超微结构观察及体视学分析 |
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| 引用本文： | 马旸,徐燕,邓廉夫.应用SOD后实验性骨痂超微结构观察及体视学分析[J].中国生化药物杂志,1998(6). |
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| 作者姓名： | 马旸 徐燕 邓廉夫 |
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| 作者单位： | 上海医药工业研究院毒理室!200437(马旸)，济宁市第一人民医药药房(徐燕)，上海市伤骨科研究所(邓廉夫) |
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| 摘 要： | 为探讨超氧化物歧化酶（SOD）对实验性骨折愈合的影响，给实验性骨折大鼠静脉注射SOD，透射电镜观察实验性骨痂组织、细胞的超微结构改变，并用微机图像处理系统对骨痂骨系细胞进行立体定量分析。结果显示：SOD可使①早期骨痂内毛细血管含量增加；②骨生成细胞增殖并向成骨细胞转化，成骨细胞数量增加，体积较大；③成骨细胞、成纤维细胞和破骨细胞功能活跃，骨痂的骨化、改建以及塑建速率加快。结论：SOD可作为促进骨折愈合的辅助药物。
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| 关 键 词： | 超氧化物歧化酶 氧自由基 骨折愈合 超微结构 立体定量 |
The Ultrastructural Observation and Stereologic Analyse of Callus in Rats after Using SOD |
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| Ma Jing, Xu Yan,Deng Lianfu.The Ultrastructural Observation and Stereologic Analyse of Callus in Rats after Using SOD[J].Chinese Journal of Biochemical Pharmaceutics,1998(6). |
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| Authors: | Ma Jing Xu Yan Deng Lianfu |
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| Abstract: | In order to investigate the effect of superoxide dismutase (SOD) on fracture healing. After using SOD,morphological changes of callus were quantitatively analysed and observed during the experimental fracture healing of rats.The results showed that osteogenic cells increased in number and differentiated into the osteoblast mainly.The osteoblast and chondrocytes were more active in forming bonytissues.Osification of callus took place early and rapidly. It's suggested that the healing of experimental fracture was expedited as a result of treatment with SOD. |
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| Keywords: | Superoxide dismutase Oxygen free-radical Fracture healing Ultrastracture Stereologican alyse |
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