| 低分子肝素联合氯吡格雷治疗短暂性脑缺血发作疗效观察 |
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| 引用本文： | 廖耿,杨职,江先娣.低分子肝素联合氯吡格雷治疗短暂性脑缺血发作疗效观察[J].临床和实验医学杂志,2007,6(5):52-53. |
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| 作者姓名： | 廖耿 杨职 江先娣 |
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| 作者单位： | 茂名市人民医院神经内科,广东,茂名,525000;茂名市人民医院神经内科,广东,茂名,525000;茂名市人民医院神经内科,广东,茂名,525000 |
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| 摘 要： | 目的观察低分子肝素和氯吡格雷治疗短暂性脑缺血发作(TIA)的临床疗效及安全性。方法选择诊断明确的TIA患者68例,随机分为治疗组和对照组。治疗组加服氯吡格雷和腹壁皮下注射低分子肝素,其余治疗同对照组。观察两组患者治疗前及治疗后脑缺血发作改善情况、脑梗死发生率、检测出凝血功能及不良反应。随访6个月。结果治疗组的TIA发作频率、脑梗死发生率明显降低,与对照组差别有显著意义(P<0.05);两组对出、凝血指标的影响无显著性差异(P>0.05)。结论低分子肝素联合氯吡格雷治疗短暂性脑缺血发作疗效显著,安全可靠。
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| 关 键 词： | 短暂性脑缺血 低分子肝素 氯吡格雷 |
| 修稿时间： | 2007-04-14 |
Effect of low molecular weight heparin (LMWH) and clopidogrel on transient ischemic attack (TIA) |
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| LIAo Geng,YANG Zhi,JIANG Xian-di.Effect of low molecular weight heparin (LMWH) and clopidogrel on transient ischemic attack (TIA)[J].Journal of Clinical and Experimental Medicine,2007,6(5):52-53. |
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| Authors: | LIAo Geng YANG Zhi JIANG Xian-di |
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| Abstract: | Objective To investigate the effectivenass and safety of LMWH and clopidogrel for TIA.Methods 68 patiens with TIA were randomly assigned to receive LMWH and clopidogre or placebo.Other treatment was the same in both groups.The length of follow-up was 6 month.Clininical effects and side effects as well as PT,APTT,PLT values were compared between two groups.Results The incidence of TIA and cerebral infarction were significantly decreased in treatment group than that in control groups(P<0.05);there were no significant difference in PT,APTT and PLT values between two groups.Conclusion Combination treatment with LMWH and clopidogrel is effetive and safe for TIA. |
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| Keywords: | TIA LMWH Clopidogrel |
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