| 不同时段睡眠剥夺对大鼠脑内c-fos表达的影响 |
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| 引用本文： | 宋国萍,皇甫恩,苗丹民,冯学文.不同时段睡眠剥夺对大鼠脑内c-fos表达的影响[J].中国临床心理学杂志,2002,10(2):103-105. |
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| 作者姓名： | 宋国萍 皇甫恩 苗丹民 冯学文 |
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| 作者单位： | 第四军医大学航空航天医学系心理教研室,陕西,西安,710032 |
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| 摘 要： | 目的 :探索睡眠剥夺的脑机制。方法 :该研究采用小平台水环境法建立大鼠睡眠剥夺模型 ,用fos蛋白免疫组化的方法测量脑中fos蛋白的表达 ,分组为白天睡眠剥夺 12h组、夜晚睡眠剥夺 12小时组、大平台对照组和正常单独饲养组 ,每组 4只。结果 :睡眠剥夺使fos蛋白在皮层的广泛区域表达 ,脑干中同异相睡眠有关的区域有较高表达 ,同夜晚睡眠剥夺 12小时相比 ,白天睡眠剥夺 12小时在视交叉上核同生物节律有关的区域表达。结论 :睡眠节律改变可影响脑内fos蛋白表达
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| 关 键 词： | 大鼠 c-fos蛋白 大脑 睡眠剥夺 |
| 文章编号： | 1005-3611(2002)02-0103-03 |
| 修稿时间： | 2001年10月17 |
C-fos Protein Expression of the Rats on the Brain after 12 Hours Sleep Deprivation of Day and Night |
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| SONG Guo-ping,HUANGFU-En,MIAO Dan-min FENG Xue-wen.C-fos Protein Expression of the Rats on the Brain after 12 Hours Sleep Deprivation of Day and Night[J].Chinese Journal of Clinical Psychology,2002,10(2):103-105. |
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| Authors: | SONG Guo-ping HUANGFU-En MIAO Dan-min FENG Xue-wen |
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| Institution: | SONG Guo-ping,HUANGFU-En,MIAO Dan-min FENG Xue-wen Department of Psychology Faculty of Aviation Medicine Fourth Military Medical University,Xi'an 710032 China |
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| Abstract: | Objective: To investigate the brain mechanisms of sleep deprivation. Methods: Sprague-Dawley rats were sleep deprived by housing them on the small platforms over water. Controls were housed in the normal cage(CC) or on the large platforms over water(TC). The effects of SD on the expression of c-fos protein by immunocytochemistry were investigated. The duration of SD was about 12 hours. They were divided into two groups: early SD group (from 7:00 am) and the late SD group (from 19:00 pm). Results: SD resulted in different expression of c-fos protein at different fields of the brain. The main fields of brain stem were all connected with paradoxical sleep. Compared with the late SD, the early SD group showed higher fos protein expression on suprachiasmatic.Conclusion: The disruption of regular circadian rhythm may affect c-fos protein expression. |
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| Keywords: | Rats c-fos protein Immunocytochemistry Brain stem Sleep deprivation Circadian Rhythm |
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