心肌梗死患者介入术前后血小板活化及纤溶功能的变化

目的 观察急性心肌梗死（AMI）患者冠状动脉介入术后外周循环血中血小板活化及凝血-纤溶功能的变化。方法 采用ELISA检测PTCA和冠状动脉内支架术前后血小板表面α-颗粒膜蛋白（GMP-140），血管性假血友病因子（vWF)，组织纤溶酶原激活剂（t-PA)，纤溶酶原激活剂抑制物-1（PAI-1），D-二聚体（D-D）的含量。结果 35例急性心肌梗死患者PTCA术后10分钟，GMP-140，tPA和vWF明显增高，术后24小时vWF仍显著增高，结论 AMI患者介入术后血小板活化和纤溶功能均出现改变。

The changes of platelet activation and fibrinolysis before and after interventional treatment in the patients with myocardial infarction.

Objective To observe the changes of the platelet activation and fibrinolysis after interventional treatment in patients with acute myocardial infarction(AMI). Methods The plasma concentration of platelet alpha-granule membrane glycoprotein-140(GMP-140), von Willebrand factor(vWF),tissue plasminogen activator(t-PA), plasminogen activator inhibitor-1(PAI-1), and D-dimer(D-D) were measured before and after percutaneous transluminal coronary angioplasty(PTCA) and coronary stenting by ELISA. Results 10 minutes after PTCA in 35 patients with AMI, GMP-140, tPA and vWF were remarkably increased. 24 hours after PTCA, vWF was still remarkably increased. Results The changes of platelet activation and fibrinolysis occur in AMI patients after interventional treatment.