Self-assembling polystyrene-block-poly(ethylene oxide) copolymer surface coatings: Resistance to protein and cell adhesion |
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| Authors: | Peter A George Bogdan C Donose Justin J Cooper-White |
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| Institution: | 1. School of Engineering and Australian Institute for Bioengineering and Nanotechnology, University of Queensland, Bld 75, Cnr Cooper and College Rds, Brisbane, QLD 4072, Australia;2. Australian National Fabrication Facility (QLD Node), University of Queensland, Bld 75, Cnr Cooper and College Rds, QLD 4072, Australia;1. Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, China;2. HGST-A Western Digital Company, 3403 Yerba Buena Road, San Jose, CA 95135, USA;3. IBM Albany NanoTech, 257 Fuller Road, Albany, NY 12203, USA;4. Institute for Molecular Engineering, University of Chicago, 5747 South Ellis Avenue, Chicago, IL 60637, USA;1. School of Chemistry and Materials Science, Liaoning Shihua University, Fushun 113001, PR China;2. State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China;3. Department of Urology, The First Hospital of Jilin University, Changchun 130021, PR China;1. 480 Stadium Mall Drive, School of Chemical Engineering, Purdue University, West Lafayette, Indiana 47907, United States;2. 182 Fitzpatrick Hall, Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, Indiana 46556, United States;3. Stanford Synchrotron Radiation Lightsource, SLAC, 2575 Sand Hill Road, Menlo Park, California 94025, United States;1. Department of Applied Chemistry and Biotechnology, Graduate School of Engineering, University of Fukui, 3-9-1 Bunkyo, Fukui 910-8507, Japan;2. Japan Science and Technology Agency, PRESTO, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan;3. School of Bioprocess Engineering, Universiti Malaysia Perlis, Kompleks Pusat Pengajian Jejawi 3, 02600 Arau, Perlis, Malaysia;4. Department of Frontier Fiber Technology and Science, Graduate School of Engineering, University of Fukui, 3-9-1 Bunkyo, Fukui 910-8507, Japan |
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| Abstract: | In this paper we report a method for biomaterial surface modification that utilizes the self-assembly of block copolymers of poly(styrene-block-ethylene oxide) (PS–PEO) to generate micro-phase separated surfaces with varying density PEO domains. These PS–PEO self-assembled surfaces showed a significant reduction in protein adsorption compared to control polystyrene surfaces. The adhesion of NIH-3T3 fibroblast cells was shown to be significantly affected by the surface coverage of PEO nano-domains formed by copolymer self-assembly. These nano-domains, when presented at high number density (almost 1000 domains per square micron), were shown to completely prevent cellular attachment, even though small amounts of protein were able to bind to the surface. |
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