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Human health risk assessment of long chain alcohols |
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| Authors: | Gauke Veenstra Catherine Webb Hans Sanderson Scott E. Belanger Peter Fisk Allen Nielsen Yutaka Kasai Andreas Willing Scott Dyer David Penney Hans Certa Kathleen Stanton Richard Sedlak |
| Affiliation: | 1. Shell International B.V., P.O. Box 162, 2501 AN The Hague, The Netherlands;2. Hayes Consultancy Service, Bromley, Kent, UK;3. The Soap and Detergent Association, Washington, DC 20005, USA;4. The Procter & Gamble Company, Central Product Safety, Miami Valley Innovation Center, P.O. Box 538707, Cincinnati, OH 45253-8707, USA;5. Peter Fisk Associates, 14 Darenth Close, Herne Bay, Kent CT6 7EX, UK;6. Sasol North America, Research and Development Department, 2201 Old Spanish Trail, Westlake, LA 70669, USA;7. Kao Corporation, 2-1-3 Bunka, Sumida-ku, Tokyo 131-8501, Japan;8. Cognis GmbH, Henkelstraße 67, D-40551 Düsseldorf, Germany;9. Department of Product Safety, Sasol North America Inc., 900 Threadneedle, Suite 100, Houston, TX 77079, USA;10. Sasol Germany GmbH, Building 1033/PB 02, Paul-Baumann-Str. 1, D-45764 Marl, Germany |
| Abstract: | Representative chemicals from the long chain alcohols category have been extensively tested to define their toxicological hazard properties. These chemicals show low acute and repeat dose toxicity with high-dose effects (if any) related to minimal liver toxicity. These chemicals do not show evidence of activity in genetic toxicity tests or to the reproductive system or the developing organism. These chemicals also are not sensitizers. Irritation is dependant on chain length; generally, alcohols in the range C6–C11 are considered as irritant, intermediate chain lengths (C12–C16) alcohols are considered to be mild irritants and chain lengths of C18 and above are considered non-irritants. These chemicals are broadly used across the consumer products industry with highest per person consumer exposures resulting from use in personal care products. Margins of exposure adequate for the protection of human health are documented for the uses of these chemicals. |
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