Engraftment of human blood malignancies to the turkey embryo: A robust new in vivo model期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Engraftment of human blood malignancies to the turkey embryo: A robust new in vivo model

Authors:	Igor Grinberg Arbel Reis Avivit Ohana Moran Taizi Michal Cipok Sigal Tavor Deborah Rund Varda R. Deutsch Ronald S. Goldstein

Affiliation:	1. Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel;2. Hematology Department, Hebrew University-Hadassah Hospital, Jerusalem, Israel;3. The Hematology Institute, Tel Aviv Tel Aviv Sourasky Medical Center, Tel-Aviv, Israel;4. Tel-Aviv University Faculty of Medicine, Tel-Aviv, Israel;1. Department of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi 110029, India;2. Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi 110029, India;1. Department of Endocrine and Breast Surgery, The First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, PR China;2. Department of Gastrointestinal Surgery, The First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, PR China;1. São Carlos Institute of Physics, University of São Paulo (USP), PO Box 369, 13560-970, São Carlos, São Paulo, Brazil;2. Institut d’Optique Graduate School, Palaiseau, France;3. Escuela Tecnica Superior de Ingenieros Aeronauticos, Universidad Politécnica de Madrid, Madrid, Spain;1. Service d’infectiologie, hôpital de l’Archet 1, centre hospitalier universitaire de Nice, BP 3079, 06202 Nice cedex 3, France;2. Pharmacie, centre hospitalier régional de Draguignan, Draguignan, France;3. Réanimation polyvalente, centre hospitalier régional de Draguignan, Draguignan, France;4. Laboratoire de biologie polyvalente, centre hospitalier régional de Draguignan, Draguignan, France;5. Département d’information médicale, centre hospitalier régional de Draguignan, Draguignan, France;1. Division of Obstetrics and Gynecology, Department of Women’s and Children’s Health, Karolinska University Hospital/Institutet, Stockholm, Sweden;2. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden;3. Regional Cancer Centre, Uppsala University Hospital, Uppsala, Sweden

Abstract:	Xenografting of human blood malignancies to immunodeficient SCID mice is a powerful research tool. We evaluate here whether the immunodeficient turkey embryo can also serve as a xenograft host for human blood malignancies. Human leukemia, lymphoma and myeloma lines engrafted robustly into medullary and extramedullary tissues of turkey embryos as detected by PCR, FACS and histology in 8–10 days. Four of eleven patient AML samples also engrafted the bone marrow. Grafts of two lines responded to chemotherapy with doxorubicin. The turkey embryo therefore has the potential to be a complementary xenograft model for the study of human blood malignancies.

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