Association of PTPN22 C1858T and CTLA-4 A49G polymorphisms with type 1 diabetes in Croatians |
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| Authors: | Marina Korolija Ivana Pavlić Renar Mirko Hadžija Edita Pape Medvidović Pajica Pavković Mladen Jokić Marijana Popović Hadžija |
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| Affiliation: | 2. Department of Neurosurgery, Ministry of Health Kirikkale Yuksek Ihtisas State Hospital, Kirikkale, Turkey;3. Department of Pathology, Ministry of Health, Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey;4. Department of Anatomy, Hacettepe University Faculty of Medicine, Ankara, Turkey;6. Department of Biochemistry, Kirikkale University Faculty of Medicine, Kirikkale, Turkey;1. Immunology Department, Habib Bourguiba Hospital, Tunisia;2. University of Sfax, Tunisia;3. Pediatric Department, Hedi Chaker Hospital, Tunisia;4. Instituto Gulbenkian de Ciência, Oeiras, Portugal |
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| Abstract: | In this case–control study the association between the PTPN22 1858T and CTLA-4 49G gene variants and T1D in Croatian population was examined. We found that distribution of PTPN22 C1858T and CTLA-4 A49G genotypes between T1D patient (n = 102) and control (n = 193) groups differ significantly (p < 0.0001 and p = 0.012, respectively). Moreover, although the risk alleles of both SNPs are distributed more frequently in patients, the significant difference is observed only for PTPN22 1858T allele (p < 0.0001). This is therefore the first evidence that analyzed gene variants contribute to T1D pathogenesis in Croatian population. |
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