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Intracellular chromosome breaks on silicon surface
Authors:Jiang Jiang  Kaifu Huo  Shaopeng Chen  Yunchang Xin  Yongjian Xu  Zhengwei Wu  Zengliang Yu  Paul K Chu
Institution:1. Key Laboratory of Ion Beam Bioengineering, Institute of Plasma Physics, Chinese Academy of Sciences, Hefei 230031, China;2. Department of Physics & Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, China;3. Hubei Province Key Laboratory of Refractories and Ceramics Ministry-Province Jointly-Constructed Cultivation Base for State Key Laboratory, College of Materials and Metallurgy, Wuhan University of Science and Technology, Wuhan 430081, China;2. Libin Cardiovascular Institute of Alberta, Calgary, Alberta, Canada;3. Quebec Heart and Lung Institute, Quebec City, Quebec, Canada;4. St. Michael’s Hospital, Toronto, Ontario, Canada;5. Montreal Heart Institute, Montreal, Quebec, Canada;11. Queen’s University, Kingston, Ontario, Canada;12. University of Ottawa Heart Institute, Ottawa, Ontario, Canada;8. Royal Jubilee Hospital, Victoria, British Columbia, Canada;9. Memorial University Health Sciences Center, St John’s Newfoundland, Canada;112. McGill University Health Center and Hôpital Sacré-Coeur de Montréal, Montreal, Quebec, Canada;123. Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada;84. BC Children’s Hospital, Vancouver, British Columbia, Canada;95. Centre Hospitalier de L-Universite de Montreal, Quebec, Canada;1111. University Hospital, Vancouver, British Columbia, Canada;1. Department of Obstetrics, Gynecology & Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA;2. Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA;1. Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA 23298-0613, United States;2. Division of the National Toxicology Program, NIEHS, RTP, NC 27709, United States
Abstract:The genotoxicity of silicon (Si) is investigated by soaking crystalline Si in a complete culture medium for 60 days and conducting micronuclei tests (MNTs) utilizing hamster ovary (CHO) cells and its Ku80 deficient CHO mutant (xrs5) cells (DNA double-strand breaks repair deficiency). The intracellular concentrations of reactive oxygen/nitrogen species (ROS/RNS) on Si are determined to elucidate the relationship between ROS/RNS and Si-induced genotoxicity by using CHO cells. The cells are treated with ROS scavenger (dimethyl sulfoxide) and MNT are performed. The results indicate that the intracellular concentration of ROS and nitrogen oxide (NO) on Si is higher than those on the control group by about 38% and 12%. ROS/RNS include superoxide (O2radical dot?) anion, NO, and peroxynitrite (ONOO?) which can injure chromosomes and induce high cellular DNA double-strand breaks (DSBs).
Keywords:
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