女性生殖道人乳头状瘤病毒感染亚型分布分析

目的 对人乳头状瘤病毒(HPV)感染人群进行调查分析,并对不同亚型HPV感染的人群分布及合并感染状况进行分析.方法 采用导流杂交技术,对妇产科门诊确诊的236例慢性宫颈炎及阴道异常出血妇女,进行阴道拭子HPV感染分型筛查.结果 在236例检测者中,HPV-DNA检测阳性172例,感染人群呈年轻化趋势;HPV 16、52、56、58亚型是中国女性中感染率较高的HPV亚型,占研究所检测常见亚型的37.0％;与其他亚型相比,HPV16和HPV18可能更容易引发多型HPV感染;在对各年龄段患者感染亚型数目的调查分析中,发现＞55岁人群中感染的HPV亚型最高.结论 HPV的感染趋于年轻化趋势,宫颈癌的发展过程与HPV的持续性感染,以及各亚型的相互作用密切相关,且高龄女性具有更高的宫颈癌患病风险,因此应增大HPV-DNA筛查力度.

Subtypes of human papilloma virus causing female genital tract infections

OBJECTIVE To investigate and analyze HPV-infected populations,and study the population distribution of different subtypes of HPV infections and the status of the infections.METHODS By the means of flow-through hybridization technology,the screening of subtypes of HPV infections in 236 women from department of gynecology and obstetrics who were diagnosed with chronic cervicitis and abnormal vaginal bleeding was performed.RESULTS Of 236 patients investigated,a total of 172 cases were tested positive for HPV-DNA,the young people were the major population infected with HPV;HPV 16,HPV 52,HPV 56,and HPV 58 were the subtypes causing the highest prevalence of infections in Chinese female,accounting for 37.0% among the common subtypes detected;and compared with other subtypes,HPV16 and HPV18 were more likely to lead to multiple-type HPV infections;the study indicated that the prevalence of HPV subtype infections was the highest among the population aged over 55 years.CONCLUSION HPV infections tend to be in younger female,the development of cervical cancer is closely related to HPV persistent infections and the interaction of various subtypes,and elderly women are at higher risk of cervical cancer,so it is necessary to intensify the screening of HPV-DNA.