老年2型糖尿病并发尿路感染的临床特点及病原体耐药性分析

目的 探讨老年2型糖尿病并发尿路感染的临床特征、病原体分布及耐药性.方法 收集2009年3月-2011年9月132例确诊为老年2型糖尿病并发尿路感染患者(感染组)的临床资料,随机抽取未并发尿路感染的132例患者为对照组,分析两组老年2型糖尿病的临床特点及病原体耐药性.结果 感染组与对照组临床特点不尽相同,感染组患者甘油三酯、尿素氮、血肌酐及治疗天数水平为(2.0212±0.1783) mmol/L、(6.5290±0.3739)mmol/L、(88.7300±5.2610) μmol/L、(15.7600±2.2520)d,与对照组比较,差异有统计学意义(P＜0.01)；在检出的264株病原体中以大肠埃希菌为主,占58.3％,感染组真菌及支原体属感染率明显高于对照组；感染组与对照组检出的病原体对抗菌药物的敏感性不尽相同,对氨苄西林耐药率为66.7％,对亚胺培南、两性霉素B及制霉菌素较为敏感.结论 2型糖尿病并发尿路感染患者具有独特的临床特征,尿路感染病原体分布特点不同,且病原体耐药率明显高于2型糖尿病未并发尿路感染患者.

Clinical characteristics of type 2 diabete mellitus in elderly patients with urinary tract infections and drug resistance of pathogens

OBJECTIVE To investigate the clinical features of type 2 diabete mellitus patients with urinary tract infections,pathogen distribution and drug resistance.METHODS We collected the clinical data of 132 elderly patients who diagnosed type 2 diabete mellitus with urinary tract infections(infection group) from Mar 2009 to Sep 2011,and 132 patients without urinary tract infections were randomly selected as the control group,the clinical characteristics of the two groups of patients with type 2 diabete mellitus and the drug resistance of pathogens.RESULTS The clinical features of the infection group varied significantly with the control group,the levels of triglycerides,urea nitrogen,serum creatinine and the treatment duration were(2.0212±0.1783)mmol/L,(6.5290±0.3739)mmol/L,(88.7300±5.2610)μmol/L,(15.7600±2.2520)d,respectively,as compared with the control group,the differences were statistically significant(P<0.01);of 264 strains of pathogens isolated,Escherichia coli was the main pathogen causing infections,accounting for 58.3%,the rates of fungal infections and Mycoplasma infections of the infection group were significantly higher than those of the control group;the pathogens detected from the infection group and the control group varied significantly in drug susceptibility,the drug resistance rate to ampicillin was 66.7%,and the isolates were susceptible to imipenem,amphotericin B and nystatin.CONCLUSION The patients with type 2 diabete mellitus and urinary tract infections have unique clinical features,the pathogens causing urinary tract infections vary in distribution,the drug resistance rate of the patients with type 2 diabete mellitus and urinary tract infections is higher than that of the type 2 diabete mellitus patients without urinary tract infections.