ICU耐甲氧西林金黄色葡萄球菌的感染现状及耐药性

目的探讨医院重症医学科中耐甲氧西林金黄色葡萄球菌(MRSA)的感染现状及耐药性,为临床合理使用抗菌药物提供必要的病原学依据。方法对医院ICU 2008年1月-2011年2月医院感染的385株金黄色葡萄球菌及其耐药性进行回顾性分析。结果 MRSA检出357株,检出率为92.8%;金黄色葡萄球菌对常用抗菌药物产生了不同的耐药性,其中对青霉素G耐药率最高,达98.6%,对万古霉素、替考拉宁和利奈唑胺敏感率最高,为100.0%。结论重症医学科中金黄色葡萄球菌的感染及耐药问题日益严重,需要加强ICU耐药菌监控,预防医院感染暴发流行。

Current status of methicillin-resistant Staphylococcus aureus infections and drug resistance

OBJECTIVE To discuss the current status of methicillin-resistant Staphylococcus aureus(MRSA) infections and its drug resistance in critical care medicine so as to provide the etiological evidence for reasonable use of antibiotics.METHODS A total of 385 strains of MRSA causing nosocomial infections from Jan 2008 to Feb 2011 and their drug resistance were analyzed retrospectively.RESULTS There were 357 strains of MRSA isolated with the detection rate of 92.8%;S.aureus varied in drug resistance to common antibiotics,the resistance rate to penicilluin G was the highest(98.6%),and the susceptibility rates to vancomycin,teicoplanin and linezolid were the highest(100.0%).CONCLUSION MRSA infections in ICU and the situation of drug resistance become increasingly serious,so it is necessary to strengthen monitoring of the resistant strains in ICU so as to prevent the outbreak and prevalence of nosocomial infections.