泌尿生殖道患者支原体属感染特点及耐药性

目的了解医院泌尿生殖道支原体属感染发生特点及耐药性。方法对2010年6月-2011年10月在医院全科及妇科门诊检查的200例患者生殖道分泌物进行支原体属检测,并同时选择10种抗菌药物进行药敏试验,对结果进行分析。结果 200例受检的标本检出支原体属阳性108例,感染率为54.00%,其中男性感染率为32.10%,女性感染率为68.91%,以解脲脲支原体(Uu)感染为主,男性与女性感染率分别为23.46%、52.94%,支原体总感染率与Uu感染率在不同性别间比较,差异有统计学意义(P<0.05);Uu对多西环素、米诺环素、交沙霉素敏感率较高,为94.44%、90.28%、93.06%,对环丙沙星、壮观霉素耐药率较高,为90.28%、77.78%;人支原体(Mh)对多西环素、米诺环素、交沙霉素敏感率均为100.00%,对罗红霉素、阿奇霉素耐药率均为100.00%;Uu+Mh对多西环素、交沙霉素敏感率高,为77.78%、72.22%,对环丙沙星、阿奇霉素耐药率较高,为94.44%、88.89%。结论泌尿生殖道患者支原体属感染率相对较为多见,其中以Uu感染为主,女性高于男性,临床一线常用药物均耐药。

Mycoplasma causing urogenital tract infections and drug resistance

OBJECTIVE To understand the incidence of urogenital tract infections caused by Mycoplasma and the drug resistance.METHODS From Jun 2010 to Oct 2011,the detection of Mycoplasma obtained from the reproductive tract secretions of 200 patients was performed,and the drug susceptibility testing for 10 antibiotics was carried out,the result was analyzed.RESULTS There were 108 of 200 patients who were detected with Mycoplasma infections with the infection rate of 54.00%,among which 32.10% were male patients and 68.91% were female patients,Uu was the major species causing infections,the infection rates of the male and female were 23.46% and 52.94%,respectively,the difference between the total prevalence of Mycoplasma infection and Uu infection in different gender patients was statistically significant(P<0.05);the drug susceptibility rates of Uu to doxycycline,minocycline,and josamycin were 94.44%,90.28%,and 93.06%,respectively,the drug resistance rates to ciprofloxacin and spectinomycin were 90.28% and 77.78%,respectively;the drug susceptibility rates of Mh to doxycycline,minocycline,and josamycin were 100.00%,the drug resistance rates to roxithromycinand azithromycin were 100.00%;the drug susceptibility rates of Uu+Mh to doxycycline and josamycin were 77.78% and 72.22%,respectively,the drug resistance rates to ciprofloxacin and azithromycin were 94.44% and 88.89%,respectively.CONCLUSION Urogenital tract infections caused by Mycoplasma is common,Uu is the predominant species;the incidence of Uu infection is higher in female than male,and it is resistant to most of the clinical first-line antibiotics.