液基细胞学检查对宫颈感染病变的临床应用

目的 探讨Auto Cyte PREP(LCT)液基细胞学对宫颈癌筛查的临床意义.方法 选择3198例体检妇女的宫颈脱落细胞作液基薄片细胞学检查,细胞学诊断采用2001年TBS诊断标准,阳性诊断包括非典型鳞状细胞(ASCUS)、低度鳞状上皮内病变(LSIL)、高度鳞状上皮内病变(HSIL)、鳞状细胞癌(SCC).结果 3198例受检者中,2283例检出感染性病变,检出率为71.39％；特异性炎症中,感染假丝酵母菌76例,感染率为2.38％,滴虫感染15例,感染率为0.47％,疱疹病毒感染5例,感染率为占0.16％,人乳头状瘤病毒(HPV)感染98例,感染率为3.06％,尖锐湿疣15例,感染率为占0.47％；轻、中度炎症、假丝酵母菌属、人乳头状瘤病毒的感染在30～39岁的人群最高,其次是40～49岁的人群,重度宫颈炎则是40～49岁的人群最高,其次是30～39岁的人群,差异均有统计学意义(P＜0.01)；ASCUS、LSIL、HSIL的检出率在40～49岁的人群最高,其次是30～39岁的人群,差异均有统计学意义(P＜0.01)；SCC检出8例,检出率为0.25％.结论 宫颈感染病及宫颈上皮内病变多集中在30～49岁的人群；LCT检查对于宫颈病变的早发现、早诊断、早治疗具有积极预防的作用.

Clinical application of liquid-based cytology in screening of cervical lesions

OBJECTIVE To explore the clinical significance of Auto Cyte PREP(LCT) liquid-based cytology in screening of cervical cancer.METHODS The cervical exfoliated cells from 3198 women undergoing physical examination were selected to perform cell liquid-based cytology test by adopting 2011 TBS diagnosis standard;the positive diagnosis included atypical squamous of undermined significance(ASCUS),lower-grade squamous intraepithelial lesions(LSIL),hower-grade squamous intraepithelial lesions(HSIL),and squamous cell carcinoma(SCC).RESULTS There were 2283(71.39%) of 3198 were detected with infectious lesions;among the population with specific inflammation,76 cases of the patients were infected with Candida(2.38%),5 patients were infected with herpesvirus(0.16%),98 patients were infected with HPV(3.06%),15 patients were with Condyloma acuminatum(0.47%);the proportion of patients with light or median inflammatory,Candida infections,and HPV infection was the largest in the group between 30 and 39 years of age,followed by the group between 40 and 49 years of age,and it was the highest in the group with severe cervicitis between 40 and 49 years of age,followed by the group between 30 and 39 years of age,the differences were statistically significant(P<0.01);the detection rates of ASCUS,LSIL,and HSIL were highest between 40 and 49 years of age,followed by the group 30~39 years of age,the difference is statistically significant(P<0.01);8 cases were detected with SCC with the detection rate of 0.25%.CONCLUSION Patients who have cervical infections and cervical intraepithelial neoplasia are mainly between 30 and 49 years;LCT examination plays an active role in early detection,diagnosis and treatment of cervical lesion.