| 细胞共培养模型在口服药物吸收研究中的应用 |
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| 引用本文： | 黎迎,朱春燕. 细胞共培养模型在口服药物吸收研究中的应用[J]. 药学实践杂志, 2015, 33(4): 289-292,327 |
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| 作者姓名： | 黎迎 朱春燕 |
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| 作者单位： | 中国医学科学院&北京协和医学院药用植物研究所, 北京 100193,中国医学科学院&北京协和医学院药用植物研究所, 北京 100193 |
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| 基金项目： | 国家自然科学基金面上项目(81274094);协和研究生创新基金项目(10023-1007-1017) |
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| 摘 要： | 细胞共培养体系能很好地模拟人体小肠生理环境,准确预测药物在肠道内的转运和代谢情况,增强体外细胞模型与整体动物实验研究之间的相关性,近年来在评价口服药物吸收方面发挥着越发重要的作用,已成为新药研发过程中评价药物口服吸收的热点。综述体外模拟肠道环境的细胞共培养模型,并对其应用于口服药物研发的体外评价吸收做出展望。
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| 关 键 词： | 细胞模型 共培养体系 口服药物 胃肠道吸收 新药筛选 |
| 收稿时间： | 2014-09-21 |
| 修稿时间： | 2015-03-05 |
Application of cell co-culture models in absorption of oral drug |
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| LI Ying and ZHU Chunyan. Application of cell co-culture models in absorption of oral drug[J]. The Journal of Pharmaceutical Practice, 2015, 33(4): 289-292,327 |
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| Authors: | LI Ying and ZHU Chunyan |
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| Affiliation: | Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China and Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China |
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| Abstract: | Cell co-culture system can better simulate the inner environment of human body, predict drug transport and metabolism in intestinal environment and increase the relation between in vitro cell model and integral animal test. In recent years, co-culture cell model plays an increasingly important role in evaluating the absorption of oral drugs, which becomes the highlight in the evaluation of drug oral absorption during new drug discovery. This essay summarized co-culture cell model which simulates intestinal environment and their application, and looked into the future of their application in evaluating oral drug intestinal absorption during oral drug discovery. |
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| Keywords: | cell model co-culture system oral drug intestinal absorption new drug screening |
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