| 苄基四氢异喹啉类生物碱的药理作用及其研究进展 |
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| 引用本文： | 赵娜,高峰,刘彬,朴贤美.苄基四氢异喹啉类生物碱的药理作用及其研究进展[J].药学实践杂志,2015,33(4):313-315,323. |
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| 作者姓名： | 赵娜 高峰 刘彬 朴贤美 |
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| 作者单位： | 哈尔滨医科大学药学院药理教研室, 黑龙江 哈尔滨 150081,哈尔滨医科大学药学院药理教研室, 黑龙江 哈尔滨 150081,哈尔滨医科大学药学院药理教研室, 黑龙江 哈尔滨 150081,哈尔滨医科大学药学院药理教研室, 黑龙江 哈尔滨 150081 |
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| 基金项目： | 黑龙江省卫生厅科研课题(2010-199); 黑龙江省青年科学基金项目(QC2013C081);哈尔滨医科大学药学院大学生创新基金项目 |
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| 摘 要： | 目的 介绍苄基四氢异喹啉生物碱的主要药理作用及其研究进展。 方法 综述苄基四氢异喹啉类化合物的生物活性、作用机制及其临床应用。 结果 苄基四氢异喹啉类生物碱具有多方面的药理学活性,尤其在抗肿瘤、抗氧化、抗炎、抗病原微生物等方面的研究进展迅速,且临床应用较为广泛。 结论 苄基四氢异喹啉类化合物具有丰富的生物学活性,研究其药理作用便于更深入地了解该类化合物的作用特点及应用前景,为该领域药物开发提供思路和启示。
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| 关 键 词： | 苄基四氢异喹啉 药理作用 作用机制 |
| 收稿时间： | 4/9/2014 12:00:00 AM |
| 修稿时间： | 1/9/2015 12:00:00 AM |
Research advance on the pharmacological effects of benzyltetrahydroisoquinolines alkaloids |
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| ZHAO N,Gao Feng,Liu Bin and PIAO Xianmei.Research advance on the pharmacological effects of benzyltetrahydroisoquinolines alkaloids[J].The Journal of Pharmaceutical Practice,2015,33(4):313-315,323. |
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| Authors: | ZHAO N Gao Feng Liu Bin and PIAO Xianmei |
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| Institution: | Department of Pharmacology, School of Pharmacy, Harbin Medicical University, 150081 China,Department of Pharmacology, School of Pharmacy, Harbin Medicical University, 150081 China,Department of Pharmacology, School of Pharmacy, Harbin Medicical University, 150081 China and Department of Pharmacology, School of Pharmacy, Harbin Medicical University, 150081 China |
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| Abstract: | Objective To introduce the major pharmacological effects and research progress of benzyltetrahydroisoquinolines alkaloids. Methods The compounds structure, biological activity, mechanism and clinical applications of benzyltetrahydroisoquinolines were reviewed based on the domestic and foreign research literatures in recent years. Results Benzyltetrahydroisoquinolines alkaloids exhibit many pharmacological activities. Researches and clinic applications on anti-tumor, anti-oxidation, anti-inflammation and anti-pathogen have been developed rapidly. Conclusion Benzyltetrahydroisoquinolines alkaloids have exhibited abundant biological activities. Studying its pharmacological effects can further the understanding of its pharmacological characteristics and application prospects, and provide thoughts and enlightenment for drug development in this field. |
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| Keywords: | benzyltetrahydroisoquinolines pharmacological effects mechanism |
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