| 联合检测血清及尿液中bcl-2与血清CA125水平对卵巢上皮性癌的诊断价值 |
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| 引用本文： | 王淑丽,苑中甫. 联合检测血清及尿液中bcl-2与血清CA125水平对卵巢上皮性癌的诊断价值[J]. 现代妇产科进展, 2010, 19(1) |
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| 作者姓名： | 王淑丽 苑中甫 |
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| 作者单位： | 郑州大学第一附属医院妇产科,郑州,450052 |
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| 摘 要： | 目的:研究凋亡相关基因bcl-2在卵巢上皮性癌患者血清及尿液的表达水平,及其与血清CA125联合检测诊断卵巢上皮性癌的临床价值。方法:采用ELISA法检测50例卵巢上皮性癌、20例卵巢良性肿瘤、18例正常人血清及尿液bcl-2水平和血清CA125水平。结果:卵巢癌患者血清及尿液bcl-2水平明显高于卵巢良性肿瘤组和正常人群组,差异有统计学意义(P0.05)。血清bcl-2水平在卵巢良性肿瘤组与正常对照组之间无显著差异(P0.05),尿液bcl-2水平在卵巢良性肿瘤组与正常对照组之间差异有统计学意义(P0.05)。血清bcl-2检测诊断卵巢癌的敏感度、特异度分别为68%、84.21%,联合血清CA125检测其敏感度、特异度分别为86%、86.84%;尿液bcl-2检测的敏感度、特异度分别为76%、89.47%,联合血清CA125检测其敏感度、特异度分别为94%、94.74%。结论:联合检测血清及尿液bcl-2与血清CA125水平有助于卵巢癌的术前诊断。
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| 关 键 词： | 卵巢肿瘤 酶联免疫吸附测定 肿瘤标记物 bcl-2 CA125 |
Clinical diagnostic value of combined detection of serum or urinary bcl-2 with serum CA125 in ovarian epithelial cancers |
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| Wang Shuli,Yuan Zhongfu. Clinical diagnostic value of combined detection of serum or urinary bcl-2 with serum CA125 in ovarian epithelial cancers[J]. Current Advances In Obstetrics and Gynecology, 2010, 19(1) |
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| Authors: | Wang Shuli Yuan Zhongfu |
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| Affiliation: | Wang Shuli,Yuan Zhongfu.Department of Obstetrics , Gynecology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052 |
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| Abstract: | Objective:To study the value of detection of urine or serum levels of bcl-2 and serum levels of CA125 in the diagnosis of ovarian epithelial carcinomas.Methods:Bcl-2 and CA125 serum levels and bcl-2 urine level were detected in patients with ovarian tumor(50 ovarian epithelial cancers,20 benign ovarian tumors)and 18 healthy women as controls by ELISA.Results:The serum bcl-2 and urinary bcl-2 levels before surgery of patients with ovarian epithelial carcinomas were higher than those of patients with ovarian ... |
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| Keywords: | bcl-2 CA125 |
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