2型糖尿病肾病患者糖化血红蛋白与尿酸检测的意义

目的探讨2型糖尿病肾病糖化血红蛋白与尿酸变化水平检测的意义。方法选择96例2型糖尿病患者做病例组,根据24h尿微量白蛋白排泄率(UAER)分为3组:正常白蛋白尿组(NAU)28例(<30mg/24h),微量白蛋白组(MAU)36例(30～299mg/24h),临床白蛋白组(CAU)32例(≥300mg/24h),30例健康人为对照组(NC),分别测定各组空腹血糖、血肌酐、糖化血红蛋白、尿酸的水平,并与对照组比较。结果 CAU组、MAU组及NAU组HbA1c、UA均高于NC组,且CAU组、MAU组与NUA组比较,HbA1c、UA显著高于NUA组(P<0.05),CAU组与MAU组比较,CAU组HbA1c、UA显著高于MAU组(P<0.05)。结论糖化血红蛋白、血尿酸对糖尿病所致肾脏损害的程度和发展有重要的临床意义。

Significance of Detecting the Level of Glycosylated Hemoglobin and Serum Uric Acid in Type 2 Diabetic Nephropathy

Objective To discuss the significance of the level of glycosylated hemoglobin（GHbA 1 c）and serum uric acid（UA）in type 2 diabetic nephropathy（DN）.Methods To choose 96 cases with diabetes.According to 24 hours urinous albumin excretion rate（UAER）,the patients were classified into three groups：normal albuminuria（NAU）（〈30 mg/24h）,microalbuminuria（MAU）（30～299mg/24h）and clinical albuminuria（CAU）（≥300mg/24h）,30 cases healthy persons as the normal control group（NC）.To detect the fasting blood glucose（FBG）,creatinine（Cr）、HbA 1 c,and UA.and compare the differences among the groups.Results GHbA 1 c and UA were increased along with UAER.The difference had statistical significance between DM group and NC group（P〈0.05）for all indexes.The difference also had statistical significance between CAU group,MAU group and NAU group（P〈0.05）. Conclusion GHbA1c and UA have great significance on the injury and development of DN.