乳腺癌钼靶X线表现与C-erbB-2癌基因相关性

目的:探讨乳腺癌钼靶X线表现与c-erbB-2癌基因表达之间的相关性。方法:将165例乳腺癌患者X线征象中钙化、边缘浸润、病变密度、是否同时合并乳腺囊性增生症与经免疫组织化学染色测定c-erbB-2基因的表达状态进行对照研究。结果:165例乳腺癌患者中,有钙化者84例,占50.91%;80例有边缘浸润,占48.40%;病变区表现为高密度87例,占52.73%;乳腺癌同时合并乳腺囊性增生症85例,占51.52%。95例c-erbB-2基因表达阳性,占57.58%。结论:乳腺癌钼靶X线征象在一定程度上反映了c-erbB-2表达状态,X线表现为钙化、边缘浸润、病变区为高密度及乳腺癌同时合并乳腺囊性增生症的乳腺癌患者c-erbB-2基因表达阳性可能性更高。

Correlativity Study on Mammographic Features and c-erbB-2 of Breast Cancer

Objective:To study the correlation between mammographic features and c-erbB-2 in breast cancer.(Methods:)The mammographic features of 165 patients with breast cancer,including calcification,infiltrated rims and density of the lesions as well as cystic hyperplasia were studied correlatively with their c-erbB-2 gene expression stained with immunohistochemical techniques.(Results):In our series of 165 cases,calcification was seen in 84 cases(50.91%),masses with infiltrated rims and high density in 80(48.40%) and 87(51.52%) cases respectively.Totally,positive c-erbB-2 expression was found in 95 of the 165 cases of breast cancer.Conclusion:Mammographic features of breast cancer,in a certain extent,reflected the status of c-erbB-2 expression.A higher positive c-erB-2 expression might probably be shown if the tumor mass consisted of some mammographic features such as calcification,infiltrated rims and high density as well as the accompany of cystic hyperplasia.