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CCR5基因多态性与尖锐湿疣的关系
引用本文:Zuo YG,Wang BX,Liu XR,Zhao P,Yan QS. CCR5基因多态性与尖锐湿疣的关系[J]. 中国医学科学院学报, 2008, 30(1): 95-97
作者姓名:Zuo YG  Wang BX  Liu XR  Zhao P  Yan QS
作者单位:中国医学科学院,北京协和医学院,北京协和医院皮肤科,北京,100730
基金项目:国家自然科学基金 , 高等学校博士学科点专项科研项目
摘    要:目的探讨CCR5△32基因多态性与尖锐湿疣的关系。方法收集60例尖锐湿疣患者和50例健康对照者的DNA标本,采用PCR方法扩增CCR5基因片段,比较两组的基因型差别。结果60例尖锐湿疣和50例健康对照者中均未发现突变型CCR5△32基因型。结论CCR5△32基因多态性与尖锐湿疣无相关性。

关 键 词:CCR5△32基因多态性  尖锐湿疣  人乳头瘤病毒  基因多态性  尖锐湿疣患者  关系  Condyloma Acuminata  Gene Polymorphism  相关性  突变型  发现  结果  差别  基因型  比较  基因片段  标本  健康  方法
文章编号:1000-503X(2008)01-0095-03
修稿时间:2007-06-01

Relationship between CCR5 gene polymorphism and condyloma acuminata
Zuo Ya-Gang,Wang Bao-Xi,Liu Xiu-Rong,Zhao Peng,Yan Qian-Shu. Relationship between CCR5 gene polymorphism and condyloma acuminata[J]. Acta Academiae Medicinae Sinicae, 2008, 30(1): 95-97
Authors:Zuo Ya-Gang  Wang Bao-Xi  Liu Xiu-Rong  Zhao Peng  Yan Qian-Shu
Affiliation:Department of Dermatology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China. zuoyagang@263.net
Abstract:OBJECTIVE: To investigate the relationship between CCR5 delta32 gene polymorphism and condyloma acuminata. METHODS: We used polymerase chain reaction to amplify the CCR5 gene fragments in 60 patients with condyloma acuminata and 50 age- and sampling date-matched controls, and compared the difference of genotypes between these two groups. RESULTS: No genotype difference was found between these two groups. CONCLUSION: Condyloma acuminata are not associated with genetic polymorphism of CCR5 delta32 gene.
Keywords:
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