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地塞米松对严重烧伤延迟复苏大鼠的炎症调控作用
引用本文:崔红,张春海,傅廷友,王光毅. 地塞米松对严重烧伤延迟复苏大鼠的炎症调控作用[J]. 实用医药杂志(山东), 2009, 26(6)
作者姓名:崔红  张春海  傅廷友  王光毅
作者单位:崔红(济南军区青岛第一疗养院,山东青岛,266071);张春海,傅廷友(401医院创伤外科,山东青岛,266100);王光毅(第二军医大学附属长海医院解放军烧伤中心,上海,200433)  
摘    要:目的探讨地塞米松在烧伤休克延迟复苏大鼠中的抗渗作用及对肿瘤坏死因子-α(TNF-α)、白介素-1β(IL-1β)、白介素-6(IL-6)的调控。方法选用SD大鼠制备烧伤和烧伤休克延迟复苏模型,随机分为假烫组、烫伤组及治疗组。伤后24h检测肺脏、肝脏及小肠的含水量及血管通透性,血浆中TNF-α、IL-1β及IL-6的浓度。结果与烫伤组相比,治疗组大鼠的肺脏、肝脏及小肠的含水量及血管通透性均显著降低,血浆中TNF-α、IL-1β及IL-6的浓度也显著降低。结论大鼠严重烧伤后,早期使用地塞米松,能下调TNF-α、IL-1β及IL-6在血浆中的总体水平,控制烧伤后过度全身炎症反应,有助于减轻脏器的水肿,从而减轻烧伤早期脏器损害。

关 键 词:烧伤  延迟复苏  地塞米松  炎性细胞因子

Regulation of Dexamethasone on Inflammation in delayed fluid resuscitation following severe thermal injury
Abstract:Objective To investigate the role of anti-permeability and regulation of dexamethasone on tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6) in delayed fluid resuscitation after severe burn. Method Sprague-Dawley rats were established as model of burned and delayed fluid resuscitation, and divided into sham group, burn group and therapy group randomly. The water content and vasopermeability of lungs,livers and intestines , level of TNF-α,IL-1βand IL-6 in sera of the rats were assayed at 24h after burned. Result As compared with burn group, water content and vasopermeability of lungs, livers and intestines,level of TNF-α, IL-1βand IL-6 in sera of the rats in therapy group depressed significantly. Conclusion Using dexamethasone after burn earlierly could down-regulate level of TNF-α, IL-1β and IL-6 in sera, and control systemic inflammatory reaction after burn, and palliate oedema and earlier damage of organs.
Keywords:Burn Delayed resuscitation Dexamethasone Inflammatory cytokine
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