乳腺浸润性导管癌生长方式的体视学参数的预后价值

目的　推荐一个乳腺浸润性导管癌的预后指标 -癌巢的表面积密度 (Sv)。方法　根据体视学原理 ,采用模板法 ,测定癌实质体积密度 (Vv)及癌巢的表面积密度 (Sv)。结果　Vv、Sv与 5年生存有显著相关性。Sv≤ 4.4的患者中 ,89.3 %生存 5年以上 ,Sv >5 .5的患者中 ,82 .5 %死于 5年以内 ,前者为 5年生存的安全值 ,后者为危险值。判别函数Sv的正判率 89.2 6 %、灵敏度 (SE) 0 .92 5 0、特异度 (SP) 0 .82 93。结论　乳腺浸润性导管癌生长方式的体视学参数Sv可作为一个可靠的预后因素提供于临床。

Prognostic evaluation of the stereological parameter of growth pattern in invasive breast duct carcinoma

Objective To recommend a prognostic factor Sv the stereological parameter of growth pattern in breast invasive duct carcinoma(IDC).Methods The volume density (Vv) of carcinomas substance and surface area density (SV) of carcinoma nests were measured in stereologic principles and by pattern method in 343 cases of IDC.Results Vv,Sv are related with survival time significantly.89.3 percent of the patients whose Sv values were no more than 4.4 survived more than 5 years,while 82.5 percent of the patients whose Sv value were more than 5.5 survived less than 5 years.The corrected rate of Sv was 89.26%,sensitivity was 0.9250,speciality was 0.8293.Conclusions Sv as a stereological parameter of growth pattern in IDC is a reliable clinical prognostic factor. [