Gene expression profiles during activation of cultured rat hepatic stellate cells by tumoral hepatocytes and fetal bovine serum |
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| Authors: | Yunhong Xia Rongxin Chen Zhenji Song Shenglong Ye Ruixia Sun Qiong Xue Zhe Zhang |
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| Affiliation: | (1) Liver Cancer Institute, Zhongshan Hospital, Fudan University, 200032 Shanghai, China;(2) Medical Department of Digestion, Zhongshan Hospital, Fudan University, 200032 Shanghai, China; |
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| Abstract: | Purpose Hepatic stellate cells (HSCs) transdifferentiate to become extracellular matrix-producing myofibroblasts during liver injury. Myofibroblasts can also promote invasion and metastasis of hepatocellular carcinoma (HCC). In this study, we determined gene expression changes in two different models of HSC activation, induction-activated HSCs (iHSCs) and culture-activated HSCs (cHSCs). |
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