丹参注射液对稳定性心绞痛患者血脂和高敏C反应蛋白影响的临床研究

目的:探讨丹参注射液对稳定性心绞痛患者血脂和C反应蛋白的影响。方法:选择我院2007年4月～2009年4月稳定性心绞痛患者83例,随机分为观察组和对照组,对照组采用扩张冠状动脉、改善心肌缺血治疗,同时口服消心痛及阿司匹林肠溶片等;观察组在对照组治疗的基础上给予丹参注射液治疗,两组患者均治疗4周。测定两组治疗前、后血脂以及高敏C反应蛋白水平;治疗后对两组患者的临床疗效和心电图疗效进行评定。结果:观察组临床治疗、心电图总有效率(93.0%、83.7%)明显高于对照组(70.0%、60.0%),差异有统计学意义(P<0.05)。两组患者治疗血脂各指标TC、TG、HDL-C、LDL-C及高敏C反应蛋白水平与本组治疗前比较,差异有统计学意义(P均<0.05);观察组治疗后血脂各指标与对照组治疗后比较,差异亦有统计学意义(P均<0.05)。结论:丹参注射液能够显著降低稳定性心绞痛血脂和高敏C反应蛋白水平,提高患者临床治疗效果,值得临床推广应用。

Clinical study on salvia injection for blood lipid and high sensitive C-reactive protein in stable angina pectoris patients

Objective：To discuss the effect of salvia injection on blood lipid and high sensitive C-reactive protein in stable angina pectoris patients.Methods：A total of 83 patients with stable angina pectoris from Apr.2007 to Apr.2009 were randomly divided into two groups.Control group was treated by dilating coronary artery and improving myocardial ischemia.Meanwhile,they took orally isosorbide dinitrate and aspirin enteric-coated tablets.Observation group was given with salvia injection on the basis of treatment in control group.Both groups were treated for 4 weeks.The blood lipid and high sensitive C-reactive protein were determined before and after treatment,and two groups＇clinical effect and electrocardiogram efficacy were evaluated after treatment.Results：The differences in clinical effect,electrocardiogram were statistical significant（P〈0.05）.Besides,indexes including TC,TG,HDL-C,LDL-C and high sensitive C-reactive protein were significantly changed after treatment（P〈0.05）,and were significantly different between two groups（P〈0.05）.Conclusions：Salvia injection can obviously decrease blood lipid and high sensitive C-reactive protein and improve clinical effect.It is worthy of clinic application.