| 血清神经元特异性烯醇化酶/癌胚抗原及胃泌素释放肽前体/癌胚抗原比值在诊断小细胞肺癌中的价值 |
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| 作者姓名： | 刘琳 朱立强 赵利 |
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| 作者单位： | 徐州医科大学附属医院检验科;徐州市肿瘤医院检验科 |
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| 摘 要： | 目的:观察肺癌患者血清中神经元特异性烯醇化酶(neuron-specificenolase,NSE)、癌胚抗原(carcinoembryonicantigen,CEA)、胃泌素释放肽前体(pro-gastrinreleasingpeptide,pro-GRP)的含量,分析NSE/CEA和pro-GRP/CEA在鉴别诊断小细胞肺癌(small cell lung cancer,SCLC)中的应用价值。方法:应用电化学发光法分别检测60例非小细胞肺癌(non-small cell lung cancer,NSCLC;肺鳞癌22例、肺腺癌38例)及45例SCLC患者血清中的NSE,pro-GRP,CEA的含量,并计算NSE/CE A和pro-GRP/CE A。利用ROC曲线确定NSE/CE A和pro-GRP/CE A鉴别诊断SCLC的最佳界值。结果:NSE/CEA值在鉴别SCLC和NSCLC的ROC曲线下面积为0.90,敏感度为88.90%,特异度85.00%,最佳判断值为3.78。pro-GRP/CE A值在鉴别SCLC和其他两种肺癌的ROC曲线下面积为0.94,敏感度为86.70%、特异度91.70%,最佳判断值为28.61。结论:NSE/CEA和pro-GRP/CEA有助于鉴别诊断SCLC和NSCLC,有较高的应用价值。
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| 关 键 词： | 小细胞肺癌 神经元特异性烯醇化酶/癌胚抗原 胃泌素释放肽前体/癌胚抗原 肿瘤标志物 鉴别诊断 |
Value of serum neuron-specific enolase/carcinoembryonic antigen and pro-gastrin releasing peptide/carcinoembryonic antigen ratio in the diagnosis of small cell lung cancer |
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| Authors: | LIU Lin ZHU Liqiang ZHAO Li |
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| Institution: | (Department of Clinical Laboratory, Affiliated Hospital of Xuzhou Medical University, Xuzhou Jiangsu 221002;Department of Clinical Laboratory, Xuzhou Tumor Hospital, Xuzhou Jiangsu 221000, China) |
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| Abstract: | LIU Lin;ZHU Liqiang;ZHAO Li(Department of Clinical Laboratory, Affiliated Hospital of Xuzhou Medical University, Xuzhou Jiangsu 221002;Department of Clinical Laboratory, Xuzhou Tumor Hospital, Xuzhou Jiangsu 221000, China) |
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| Keywords: | small cell lung cancer neuron-specific enolase/carcinoembryonic antigen pro-gastrin releasing peptide/ carcinoembryonic antigen tumor markers differential diagnosis |
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