High-field,high-resolution,susceptibility-weighted magnetic resonance imaging: improved image quality by addition of contrast agent and higher field strength in patients with brain tumors |
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Authors: | K Pinker I M Noebauer-Huhmann I Stavrou R Hoeftberger P Szomolanyi M Weber A Stadlbauer G Grabner E Knosp S Trattnig |
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Institution: | (1) MR Centre of Excellence, Department of Radiology, Medical University Vienna, Lazarettg. 14, 1090 Vienna, Austria;(2) Department of Neurosurgery, Medical University Vienna, Vienna, Austria;(3) Institute of Neurology, Medical University Vienna, Vienna, Austria;(4) Department of Neurosurgery, University Erlangen-Nuremberg, Erlangen, Germany |
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Abstract: | Introduction To demonstrate intratumoral susceptibility effects in malignant brain tumors and to assess visualization of susceptibility
effects before and after administration of the paramagnetic contrast agent MultiHance (gadobenate dimeglumine; Bracco Imaging),
an agent known to have high relaxivity, with respect to susceptibility effects, image quality, and reduction of scan time.
Methods Included in the study were 19 patients with malignant brain tumors who underwent high-resolution, susceptibility-weighted
(SW) MR imaging at 3 T before and after administration of contrast agent. In all patients, Multihance was administered intravenously
as a bolus (0.1 mmol/kg body weight). MR images were individually evaluated by two radiologists with previous experience in
the evaluation of pre- and postcontrast 3-T SW MR images with respect to susceptibility effects, image quality, and reduction
of scan time.
Results In the 19 patients 21 tumors were diagnosed, of which 18 demonstrated intralesional susceptibility effects both in pre- and
postcontrast SW images, and 19 demonstrated contrast enhancement in both SW images and T1-weighted spin-echo MR images. Conspicuity
of susceptibility effects and image quality were improved in postcontrast images compared with precontrast images and the
scan time was also reduced due to decreased TE values from 9 min (precontrast) to 7 min (postcontrast).
Conclusion The intravenous administration of MultiHance, an agent with high relaxivity, allowed a reduction of scan time from 9 min to
7 min while preserving excellent susceptibility effects and image quality in SW images obtained at 3 T. Contrast enhancement
and intralesional susceptibility effects can be assessed in one sequence. |
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Keywords: | High field 3 Tesla Susceptibility-weighted magnetic resonance imaging Contrast agent Brain tumors |
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