PET imaging of the brain serotonin transporters (SERT) with N,N-dimethyl-2-(2-amino-4-[18F]fluorophenylthio)benzylamine (4-[18F]-ADAM) in humans: a preliminary study |
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Authors: | Wen-Sheng Huang San-Yuan Huang Pei-Shen Ho Kuo-Hsing Ma Ya-Yao Huang Chin-Bin Yeh Ren-Syuan Liu Cheng-Yi Cheng Chyng-Yann Shiue |
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Affiliation: | 1. Department of Nuclear Medicine, PET Center, Tri-Service General Hospital, 325 Sec. 2, Cheng-Kung Rd, Neihu, 11490, Taipei, Taiwan 6. Department of Nuclear Medicine, Changhua Christian Hospital, Changhua, 50006, Taiwan 2. Department of Psychiatry, Tri-Service General Hospital, Taipei, Taiwan 3. Department of Biology and Anatomy, National Defense Medical Center, 161 Sec. 6, Min-Chuan East Rd, Taipei, 11490, Taiwan 4. Department of Nuclear Medicine, PET Center, National Taiwan University Hospital, 7, Chung-Shan S. Rd, Taipei, 100, Taiwan 5. Department of Nuclear Medicine, Taipei Veterans General Hospital, 201 Sec. 2, Shih-Pai Rd, Taipei, 11217, Taiwan
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Abstract: | Purpose The aim of this study was to assess the feasibility of using 4-[18F]-ADAM as a brain SERT imaging agent in humans. Methods Enrolled in the study were 19 healthy Taiwanese subjects (11 men, 8 women; age 33?±?9?years). The PET data were semiquantitatively analyzed and expressed as specific uptake ratios (SUR) and distribution volume ratios (DVR) using the software package PMOD. The SUR and DVR of 4-[18F]-ADAM in the raphe nucleus (RN), midbrain (MB), thalamus (TH), striatum (STR) and prefrontal cortex (PFC) were determined using the cerebellum (CB) as the reference region. Results 4-[18F]-ADAM bound to known SERT-rich regions in human brain. The order of the regional brain uptake was MB (RN) > TH > STR > PFC > CB. The DVR (n?=?4, t*?=?60?min) in the RN, TH, STR and PFC were 3.00?±?0.50, 2.25?±?0.45, 2.05?±?0.31 and 1.40?±?0.13, respectively. The optimal time for imaging brain SERT with 4-[18F]-ADAM was 120?C140?min after injection. At the optimal imaging time, the SURs (n?=?15) in the MB, TH, STR, and PFC were 2.25?±?0.20, 2.28?±?0.20, 2.12?±?0.18 and 1.47?±?0.14, respectively. There were no significant differences in SERT availability between men and women (p?0.05). Conclusion The results of this study showed that 4-[18F]-ADAM was safe for human studies and its distribution in human brain appeared to correlate well with the known distribution of SERT in the human brain. In addition, it had high specific binding and a reasonable optimal time for imaging brain SERT in humans. Thus, 4-[18F]-ADAM may be feasible for assessing the status of brain SERT in humans. |
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